Abstract
The relationship between oestrogen receptor (RE) content of primary breast cancer and subsequent prognosis was examined with regard to nodal status. It was found that, within a particular nodal group, patients with tumours containing fully functional RE experienced a longer disease-free interval than those with RE- disease. An earlier observation that RE- primary disease gave rise to distant metastases as first site of recurrence more frequently than did RE+ disease, was not sustained. However, patients with RE+ primary disease had a much reduced chance of dying from cancer within a 3-year period.
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Leake, R., Laing, L., McArdle, C. et al. Soluble and nuclear oestrogen receptor status in human breast cancer in relation to prognosis. Br J Cancer 43, 67–71 (1981). https://doi.org/10.1038/bjc.1981.9
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DOI: https://doi.org/10.1038/bjc.1981.9
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