Abstract
Nucleic acid extracts from transplantable carcinomas Vx7 and Vx2, long maintained in domestic rabbits, were assayed for their ability to produce papillomas in animals of this kind. The Vx7 had been serially transferred 111 times when this was attempted and Vx2 was in its 203rd generation. The nucleic acid extracts from the Vx7 carcinomas consistently yielded papillomas whereas those from Vx2 completely failed to do so. The tumorigenicity of the Vx7 extracts was slight and regression of the induced papillomas often took place, as happens not infrequently to the growths caused by nucleic acid extracts obtained directly from papillomas. Malignant conversion, a common event in tumors induced by Shope papilloma virus, was also observed to occur among papillomas which were induced by the nucleic acid extracts from Vx7 carcinomas, and which kept persisting over a year on the skin of experimental animals.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Ito, Y. Induction of Papillomas in Rabbits with Nucleic Acid Extracts from Vx7 Carcinomas. Br J Cancer 24, 535–541 (1970). https://doi.org/10.1038/bjc.1970.64
Issue Date:
DOI: https://doi.org/10.1038/bjc.1970.64
This article is cited by
-
Enhancement of u.v.-induced skin carcinogenesis in the hairless mouse by inoculation with cell-free extracts of skin tumours
Immunology and Cell Biology (1989)