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Studies of the Rat Immune Response to Plasmacytoma 5563 in C3H Mice

British Journal of Cancer volume 24, pages 853–860 (1970)Cite this article

Abstract

Washed lymphocytes from immunized rats showed no reaction against mouse plasmacytoma 5563 in vivo or in vitro.

Cell-free lymph from immunized rats was shown to be cytotoxic to the tumour cells in vitro. This effect we have shown to be solely in the 19s fraction after Sephadex G-200 separation.

This 19s fraction conferred partial protection to tumour bearing mice when given shortly after transplantation, but had negligible effect against late well established tumour.

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Authors
  1. O Fakhri
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  2. J R Hobbs
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Fakhri, O., Hobbs, J. Studies of the Rat Immune Response to Plasmacytoma 5563 in C3H Mice. Br J Cancer 24, 853–860 (1970). https://doi.org/10.1038/bjc.1970.101

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  • DOI: https://doi.org/10.1038/bjc.1970.101

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