Abstract
Aim:
To investigate the effect of jujuboside A (JuA) on modulating gene expression in the hippocampus.
Methods:
The spontaneous activity of mice was monitored, and the differential display polymerase chain reaction was adapted to screen differentially-expressed genes modulated by JuA in the mouse hippocampus.
Results:
JuA significantly decreased the total activity intensity (P<0.01 vs control) at a dosage of 80 mg/kg, and the genes MAP/microtubule affinity-regulating kinase3 (Mark3) and retinitis pigmentosa GTPase regulator interacting protein 1 (Rpgrip1) were upregulated by JuA in the mouse hippocampus.
Conclusion:
JuA had an inhibitory effect on the spontaneous activity of the mice, and JuA regulated the transcription of Mark3 and Rpgrip1 in the mouse hippocampus.
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Project supported by a grant from the National Science Fund for Distinguished Young Scholars (No 30525030)and from Key Technologies R&D Program of Sichuan Province.
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Wang, C., You, Zl., Xia, Q. et al. Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus. Acta Pharmacol Sin 28, 334–338 (2007). https://doi.org/10.1111/j.1745-7254.2007.00497.x
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DOI: https://doi.org/10.1111/j.1745-7254.2007.00497.x
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