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Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus

Cancer Gene Therapy volume 7, pages 1421–1425 (2000)Cite this article

Abstract

The absence of expression of the p16INK4a gene product is observed in virtually all mesothelioma tumors and cell lines, whereas wild-type pRB expression is maintained. We have examined the potential therapeutic role of re-expressing the p16INK4a gene product in mice with established human mesothelioma xenografts. Experiments using Adp16 treatments in mesothelioma xenografts demonstrated prolonged survival and potential cure following treatment with p16INK4a-based gene therapy. These results demonstrate that p16INK4a gene transfer may play a therapeutic role in the treatment of mesothelioma. Cancer Gene Therapy (2000) 7, 1421–1425

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Authors and Affiliations

  1. The Department of Medicine and Research Service, Minneapolis Veterans Affairs Medical Center, University of Minnesota Medical School, Minneapolis, 55417, Minnesota

    Sandra P Frizelle, Jeffrey B Rubins, Joan X Zhou & Robert A Kratzke

  2. Department of Medicine, Pulmonary and Critical Care Medicine, University of Minnesota Medical School, Minneapolis, 55417, Minnesota

    Jeffrey B Rubins

  3. Gene Therapy Program, University of Alabama, Birmingham, 35294, Alabama

    David T Curiel

  4. Department of Medicine, Sections of Hematology/Oncology/Transplant, University of Minnesota Medical School, Minneapolis, 55417, Minnesota

    Robert A Kratzke

Authors
  1. Sandra P Frizelle
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  2. Jeffrey B Rubins
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  3. Joan X Zhou
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  4. David T Curiel
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  5. Robert A Kratzke
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Correspondence to Robert A Kratzke.

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Frizelle, S., Rubins, J., Zhou, J. et al. Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus. Cancer Gene Ther 7, 1421–1425 (2000). https://doi.org/10.1038/sj.cgt.7700241

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  • DOI: https://doi.org/10.1038/sj.cgt.7700241

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