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Hypoxic respiratory failure: etiology and outcomes at one referral center 2000 through 2005

Journal of Perinatology volume 27, pages 371–374 (2007)Cite this article

Abstract

Objective:

We calculated in a referral population of term and near-term infants with hypoxic respiratory failure (HRF) as a primary presenting problem the overall survival rate, the need for extracorporeal membrane oxygenation (ECMO) and the incidence of apparently irreversible disorders.

Study Design:

All infants ⩾36-week gestation admitted at ⩽72 h of age from 2000 through 2005 were identified. The worst (highest) oxygen index (OI) was calculated and outcomes were noted.

Results:

A total of 630 infants were reviewed and 315 infants were identified with primary diagnosis of HRF; four infants died before discharge. One hundred seventy-seven infants had OI ⩽14; 71 had OI of 15 to 25; and 67 had OI of >25. A total of 32 infants received ECMO, including all four who died, two with histologic evidence of pulmonary malformations and two with septic shock.

Conclusion:

Term or near-term infants with isolated HRF are likely to survive, given the low incidence of pulmonary disorders not supportable by inhaled nitric oxide or ECMO.

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Acknowledgements

This work was presented in part at the Pediatric Academic Societies annual meeting, Washington, DC, 2005. The authors thank Mary S Bailey for her administrative assistance with this article and Susannah P Dillender, MD for her assistance with reviewing transport records. This study was supported in part by: Children's Mercy Hospitals and Clinics Physician Scientist Award, Sosland Endowed Chair in Neonatal Research and NIH R-01 70560 (WET).

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Authors and Affiliations

  1. Department of Pediatrics, Children's Mercy Hospitals and Clinics, Section of Neonatology, Kansas City, MO, USA

    W E Truog, G Kurth, B Haney & H W Kilbride

  2. University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA

    W E Truog & H W Kilbride

Authors
  1. W E Truog
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  2. G Kurth
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  3. B Haney
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  4. H W Kilbride
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Correspondence to W E Truog.

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Truog, W., Kurth, G., Haney, B. et al. Hypoxic respiratory failure: etiology and outcomes at one referral center 2000 through 2005. J Perinatol 27, 371–374 (2007). https://doi.org/10.1038/sj.jp.7211753

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