Abstract
Objective:
Oxygen toxicity is thought to contribute to the development of bronchopulmonary dysplasia (BPD). Oxidant injury leads to formation of F2-isoprostanes (F2-IsoP). We hypothesized that urinary excretion of the stable metabolite of F2-IsoP, 8-iso-PGF2α, would be higher in infants who develop BPD than those who did not.
Methods:
Forty infants <30-weeks gestational age (GA) were enrolled, 24 infants with BPD and 16 without BPD. Urine specimens were collected weekly and stored at −80°C until analyzed. Urinary 8-iso-PGF2α was measured by gas chromatography/mass spectrometry (GC-MS) and normalized to creatinine excretion.
Results:
GA and birth weight (BW) were lower in infants who developed BPD than those who did not. Urinary 8-iso-PGF2α levels in the first or third weeks of age were not significantly different between the two groups.
Conclusion:
Urinary excretion of 8-iso-PGF2α in early postnatal life in preterm infants is not correlated with the development of BPD.
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Acknowledgements
The authors thank Dr Jason Morrow from Vanderbilt University for his assistance with the GC-MS protocol.
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Reuter, S., O'Donovan, D., Hegemier, S. et al. Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia. J Perinatol 27, 303–306 (2007). https://doi.org/10.1038/sj.jp.7211684
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DOI: https://doi.org/10.1038/sj.jp.7211684