Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perinatal/Neonatal Case Presentation
  • Published:

Perinatal/Neonatal Case Presentation

Recombinant activated factor seven in acute life-threatening bleeding in neonates: report on three cases and review of literature

Journal of Perinatology volume 26, pages 706–713 (2006)Cite this article

Abstract

Introduction:

Acute bleeding of different genesis can be a severe, life-threatening problem in neonatology. Recombinant factor seven (rFVIIa) is known to have unique hemostatic properties in adults and older children.

Case presentation:

Three cases of acute life-threatening peri- and postnatal hemorrhage were successfully controlled after the application of fFVIIa. All infants were first treated with vitamin K, fresh-frozen plasma and platelet transfusion.

Conclusion:

The cases substantiate other reports that rFVIIa is an effective treatment for acute, refractory and life-threatening bleeding in neonates and premature infants.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Article 16 February 2023

Evdokia Dimitriadis, Daniel L. Rolnik, … Ellen Menkhorst

References

  1. Heuer L, Blumenberg D . Recombinant factor VIIa (NovoSeven®). A review of current and possible future indications. Anaesthesist 2002; 51: 388–399.

    Article  CAS  Google Scholar 

  2. Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN et al. Recombinant activated factor VII for acute intracerebral hemorrhage. New Engl J Med 2005; 352: 777–785.

    Article  CAS  Google Scholar 

  3. Chuansumrit A, Visanuyothin N, Puapunwattana S, Chaivisuth A, Rasmidat P, Charoenkwan P et al. Outcome of intracranial hemorrhage in infants with congenital factor VII deficiency. J Med Assoc Thai 2002; 85(S4): 1059–1064.

    Google Scholar 

  4. Wong WY, Huang WC, Miller R, McGinty K, Whisnat JK . Clinical efficacy and recovery levels of recombinant FVIIa (Novoseven) in the treatment of intracranial haemorrhage in severe neonatal FVII deficiency. Haemophilia 2000; 6: 50–54.

    Article  CAS  Google Scholar 

  5. Tancabelic J, Haun SE . Management of coagulopathy with recombinant factor VIIa in a neonate with echovirus type 7. Pediatr Blood Cancer 2004; 43: 170–176.

    Article  Google Scholar 

  6. Wittenstein B, Ng C, Ravn H, Goldmann A . Recombinant factor VII for severe bleeding during extracorporeal membrane oxygenation following open heart surgery. Pediatr Crit Care Med 2005; 6: 473–476.

    Article  Google Scholar 

  7. Velik-Salchner C, Sergi C, Fries D, Moser P, Streif W, Kolbitsch C . Use of recombinant factor VIIa (Novoseven) in combination with other products led to a thrombotic occlusion of the truncus brachiocephalicus in a neonate supported by exracorporal membrane oxygenation. Anesth Analg 2005; 101: 924.

    Article  Google Scholar 

  8. Razon Y, Erez E, Vidne B, Birk E, Katz J, Tamari H et al. Recombinant factor VIIa (NovoSeven®) as a hemostatic agent after surgery for congenital heart disease. Pediatric Anesth 2005; 15: 235–240.

    Article  Google Scholar 

  9. Girisch M, Rauch R, Carbon R, Habash T, Hofbeck M . Refractory bleeding following major surgery of a giant teratoma in a premature infant: succesful use of recombinant factor VIIa. Eur J Pediatr 2004; 163: 118–119.

    Article  Google Scholar 

  10. Millar CG, Stringer MD, Sugarman I, Richards M . The use of recombinant factor VIIa for bleeding in paediatric practice. Haemophilia 2005; 11: 171–174.

    Article  CAS  Google Scholar 

  11. Veldman A, Fischer D, Voigt B, Beyer PA, Schlösser R, Allendorf A et al. Life-threatening hemorrhage in neonates management with recombinant activated factor VII. Intens Care Med 2002; 28: 1635–1637.

    Article  Google Scholar 

  12. Filan PM, Mills JF, Clarnette TD, Ekert H, Ekert P . Spontaneous liver hemorrhage during laparotomy for necrotizing enterocolitis: a potential role for recombinant factor VIIa. J Pediatr 2005; 147: 857–859.

    Article  CAS  Google Scholar 

  13. Chuansumrit A, Nuntnarumit P, Okascharoen C, Teerakatkul S, Suwansingh S, Supapannachart S . The use of recombinant activated factor VII to control bleeding in a preterm infant undergoing exploratory laparotomy. Pediatrics 2002; 107: 169–170.

    Article  Google Scholar 

  14. Olomu N, Kulkarni N, Manco-Johnson M . Treatment of severe pulmonary hemorrhage with activated recombinant factor VII (rFVIIa) in very low birth weight infants. J Perinatol 2002; 22: 672–674.

    Article  Google Scholar 

  15. Villar A, Aronis S, Morfini M, Santagostino E, Auerswald G, Thomsen HF et al. Pharmacokinetics of activated recombinant coagulation factor VII (NovoSeven) in children vs adults with haemophilia A. Haemophilia 2004; 10: 352–359.

    Article  CAS  Google Scholar 

  16. Fontaine MJ, Lazarchick J, Taylor S, Annibale D . Use of recombinant factor VIIa in Infants with severe coagulopathy. J Perinatol 2004; 24: 310–311.

    Article  CAS  Google Scholar 

  17. Greisen G, Andreasen RB . Recombinant factor VIIa in preterm neonates with prolonged prothrombin time. Blood Coagul Fibrinolysis 2003; 14: 117–120.

    Article  CAS  Google Scholar 

  18. Maimon M, Bernstein T, Kenet G, Kapelushnik J . Recombinant factor VIIa for treatment of a child with severe factor VII deficiency and coarctation of the aorta. J Pediatr Hematol Oncol 2003; 25: 591.

    Article  Google Scholar 

  19. Tokunaga C, Hiramatsu Y, Horigome H, Takahashi-Igari M, Noma M, Sakakibara Y . Palliative open heart surgery in an infant with factor VII deficiency. Ann Thorac Surg 2003; 76: 2093–2094.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neonatology, Children's Hospital of the University of Cologne, Cologne, Germany

    C Hünseler, A Kribs, F Eifinger & B Roth

Authors
  1. C Hünseler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Kribs
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F Eifinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B Roth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C Hünseler.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hünseler, C., Kribs, A., Eifinger, F. et al. Recombinant activated factor seven in acute life-threatening bleeding in neonates: report on three cases and review of literature. J Perinatol 26, 706–713 (2006). https://doi.org/10.1038/sj.jp.7211588

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7211588

Keywords

This article is cited by

Search

Advanced search

Quick links