Abstract
Objective:
To determine whether an isolated finding of a choroid plexus cyst (CPC) during routine ultrasound is associated with altered fetal growth or development.
Study design:
Prospective, case–control study comparing 35 CPC cases to 67 controls. Neurobehavioral development assessment included 50 min long serial recordings of heart rate, motor activity and their interrelation at 24, 28, 32 and 36 weeks gestation. Growth measurement was based on three ultrasound evaluations of femur length, biparietal diameter, head circumference and abdominal circumference at initial exam, 28 and 36 weeks.
Results:
Longitudinal analyses revealed no differences in fetal heart rate, variability or accelerations; the number or duration of fetal movements or total motor activity; nor fetal movement-fetal heart rate coupling. CPC cases had slightly smaller head and abdominal circumferences at 28 weeks, but these differences had disappeared by 36 weeks. CPC detection was more common when routine exams were conducted earlier (18.8 versus 19.5 weeks; P<0.01).
Conclusion:
Despite the presumption that CPCs with normal karyotypes are benign variants, little empirical support exists. These results indicate that CPCs detected by prenatal ultrasound do not pose or reveal a threat to fetal development.
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References
Brown T, Kliewer M, Hertzberg B, Ruiz C, Stamper T, Rosnes J et al. A role for maternal serum screening in detecting chromosomal abnormalities in fetuses with isolated choroid plexus cysts: a prospective multicentre study. Prenat Diagn 1999; 19: 405–410.
Chinn D, Miller E, Worthy L, Towers C . Sonographically detected fetal choroid plexus cysts. Frequency and association with aneuploidy. J Ultrasound Med 1991; 10: 255–258.
Kupferminc M, Tamura R, Sabbagha R, Parilla B, Cohen L, Pergament E . Isolated choroid plexus cyst(s): an indication for amniocentesis. Am J Obstet Gynecol 1994; 171: 1068–1071.
Yoder P, Sabbagha R, Gross S, Zelop C . The second-trimester fetus with isolated choroid plexus cysts: a meta-analysis of risk of trisomies 18 and 21. Obstet Gynecol 1999; 93: 869–872.
Doubilet P, Copel J, Benson C, Bahado-Singh R, Platt L . Choroid plexus cyst and echogenic intracardiac focus in women at low risk for chromosomal anomalies. J Ultrasound Med 2004; 23: 883–885.
Filly R, Benacerraf B, Nyberg D, Hobbins J . Choroid plexus cyst and echogenic intracardiac focus in women at low risk for chromosomal anomalies. J Ultrasound Med 2004; 23: 447–449.
Sepulveda W, Lopez-Tenorio J . The value of minor ultrasound markers for fetal aneuploidy. Curr Opin Obstet Gynecol 2001; 13: 183–191.
Walkinshaw S . Fetal choroid plexus cysts: are we there yet? Prenat Diagn 2000; 20: 657–662.
Chudleigh P, Pearce JM, Campbell S . The prenatal diagnosis of transient cysts of the fetal choroid plexus. Prenat Diagn 1984; 4: 135–137.
Digiovanni L, Quinlan M, Verp M . Choroid plexus cysts: infant and early childhood developmental outcome. Obstet Gynecol 1997; 90: 191–194.
Bernier F, Crawford S, Dewey D . Developmental outcome of children who had choroid plexus cysts detected prenatally. Prenat Diagn 2005; 25: 322–326.
Horimoto N, Koyangi T, Maeda H, Satoh S, Takashima T, Minami T et al. Can brain impairment be detected by in utero behavioural patterns? Arch Dis Child 1993; 69: 3–8.
Nijhuis I, ten Hof J, Mulder E, Nijhuis J, Narayan H, Taylor D et al. Fetal heart rate in relation to its variation in normal and growth retarded fetuses. Eur J Obstet Gynecol Reprod Biol 2000; 89: 27–33.
Robertson SS, Dierker LJ . The development of cyclic motility in fetuses of diabetic mothers. Dev Psychobiol 1985; 19: 223–234.
Wouldes T, Roberts A, Pryor J, Bagnall C, Gunn T . The effect of methadone treatment on the quantity and quality of human fetal movement. Neurotoxicol Teratol 2004; 26: 23–34.
DiPietro JA, Caulfield LE, Costigan KA, Merialdi M, Nguyen RHN, Zavaleta N et al. Fetal neurobehavioral development: a tale of two cities. Dev Psychol 2004; 40: 445–456.
Krasnegor N, Fifer W, Maulik D, McNellis D, Romero R, Smotherman W . Fetal behavioral development: a transdisciplinary perspective for assessing fetal well-being and predicting outcome. Prenat Neonat Med 1998; 3: 185–190.
Nijhuis JG . Fetal behavior. Neurobiol Aging 2004; 24: S41–S46.
Kraus I, Jirasek J . Some observations of the structure of the choroid plexus and its cysts. Prenat Diagn 2002; 22: 1223–1228.
Kennedy K, Carey J . Choroid plexus cysts: significance and current management practices. Semin Ultrasound CT MR 1993; 14: 23–30.
DiPietro JA, Costigan KA, Pressman EK . Fetal movement detection: comparison of the Toitu actograph with ultrasound from 20 weeks gestation. J Matern Fetal Med 1999; 8: 237–242.
Maeda K, Tatsumura M, Utsu M . Analysis of fetal movements by Doppler actocardiogram and fetal B-mode imaging. Clin Perinatol 1999; 26: 829–851.
DiPietro JA, Hodgson DM, Costigan KA, Hilton SC, Johnson TRB . Development of fetal movement – fetal heart rate coupling from 20 weeks through term. Early Hum Dev 1996; 44: 139–151.
Zeger S, Liang K . Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986; 42: 121–130.
Cristofalo E, DiPietro J, Costigan K, Nelson P, Crino J . Women's response to fetal choroid plexus cysts detected by prenatal ultrasound. J Perinatol 2006; 26: 215–223.
Landy H, Bannon P, Zalud I, Collea J, Lewis K, Bartholomew M et al. Association of sex of the fetus in isolated fetal choroid plexus cysts. J Ultrasound Med 1999; 18: 769–771.
Acknowledgements
This research was supported by an award from the National Institute of Child Health and Human Development, R01 HD27592, and The Thomas Wilson Sanitarium for the Children of Baltimore City, awarded to the first and third authors, respectively.
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DiPietro, J., Costigan, K., Cristofalo, E. et al. Choroid plexus cysts do not affect fetal neurodevelopment. J Perinatol 26, 622–627 (2006). https://doi.org/10.1038/sj.jp.7211574
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DOI: https://doi.org/10.1038/sj.jp.7211574