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  • Letter to the Editor
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Response

Journal of Perinatology volume 24, pages 267–268 (2004)Cite this article

We would like to thank Fernandes and his colleagues for their insight and thoughtful comments on our manuscript.1 We appreciate the authors’ critical analysis of our results. We were also somewhat puzzled by our own results as the authors and have discussed the results of our study primarily in light of our clinical experience keeping the limitations of the retrospective nature of the data in mind and providing minimal speculative arguments.

We did not include the comparative data on weight increase in the conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFOV) groups since the increased volume of distribution in the HFOV group has the same meaning. The average weight gain in the HFOV group was almost twice that of the CMV group; however, when individual patient data were examined in this group this did not appear to be the case. This fact indicates the variability in patient response. The expression of calculated Vd expressed as mean±SD may also be somewhat misleading due to small sample size. The authors’ explanation of the fluid overload may be valid but for some of our patients only. Comparison of this study to our other work2,3,4 is not possible as the clinical situations are very different (extracorporeal membrane oxygenation vs HFOV).

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References

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Authors and Affiliations

  1. University of Michigan Ann Arbor, MI, USA

    Varsha Bhatt-Mehta PharmD, FCCP & Steven M Donn MD

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  1. Varsha Bhatt-Mehta PharmD, FCCP
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  2. Steven M Donn MD
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Bhatt-Mehta, V., Donn, S. Response. J Perinatol 24, 267–268 (2004). https://doi.org/10.1038/sj.jp.7211117

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