Abstract
Classical serologic assays are not useful for the diagnosis of perinatal herpes simplex virus (HSV) infection during the acute phase of the disease. We report two cases of neonatal HSV infection that highlight the diagnostic value of HSV-specific IgG avidity and its contribution for further characterization of neonatal HSV infection.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kohl S . Neonatal herpes simplex virus infection Rev Clin Perinatol 1997 24: 129–50
Hedman K, Lappalainen M, Söderlund M, Hedman L . Avidity of IgG in serodiagnosis of infectious diseases Rev Med Microbiol 1993 4: 123–9
Grangeot-Keros L, Mayaux MJ, Lebon P et al. Value of cytomegalovirus (CMV) IgG avidity index for the diagnosis of primary CMV infection in pregnant women J Infect Dis 1997 175: 944–6
Dussaix E, Chantot S, Harzic M, Grangeot-Keros L . CMV-IgG avidity and CMV-IgM concentration in both immunocompromised and immunocompetent patients Pathol Biol (Paris) 1996 44: 405–10
Ruellan-Eugene G, Barjot P, Campet M et al. Evaluation of virological procedures to detect fetal human cytomegalovirus infection: avidity of IgG antibodies, virus detection in amniotic fluid and maternal serum J Med Virol 1996 50: 9–15
Ward KN, Gray JJ, Fotheringham MW, Sheldon MJ . IgG antibodies to human herpes-virus-6 in young children: changes in avidity of antibody correlate with time after infection J Med Virol 1993 39: 131–8
De Ory F, Antonaya J, Fernandez MV, Echevarria JM . Application of low-avidity immunoglobulin G studies to diagnosis of Epstein-Barr virus infectious mononucleosis J Clin Microbiol 1993 31: 1669–71
Thomas HIJ, Morgan-Capner P . The use of antibody avidity measurements for the diagnosis of rubella Rev Med Virol 1991 1: 41–50
Hashido M, Inouye S, Kawana T . Differentiation of primary from nonprimary genital herpes infections by a herpes simplex virus-specific immunoglobulin G avidity assay J Clin Microbiol 1997 35: 1766–8
Gutierrez J, Rodriguez M, Maroto MC, Piedrola G, Peiron J . Behaviour of IgG antibody avidity for the antigen and of IgA antibody in active cytomegalovirus, Epstein-Barr virus, herpes simplex virus and human herpes virus 6 infections. Adaptation of a commercial test J Infect 1997 35: 25–30
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Odièvre, MH., Cointe, D., Thébaud, B. et al. The Assessment of IgG Avidity in the Evaluation of Perinatal Herpes Simplex Virus Infection. J Perinatol 22, 669–671 (2002). https://doi.org/10.1038/sj.jp.7210781
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.jp.7210781