Abstract
Thus far, studies investigating the differences in tumour characteristics between breast cancer in BRCA1-carriers and other patients, have focused on highly selected groups of patients, potentially limiting the conclusions that can be drawn. Previously, we had identified 10 patients with BRCA1 germline mutations in a hospital-based series of 642 breast cancer patients not selected for age or family history. The aim of this analysis is to investigate the clinical and pathological features of these BRCA1 associated carcinomas as compared to other breast cancers in this representative sample. Tumours from patients with BRCA1 germline mutations (n= 10) were compared to an age-matched sample of other patients (n= 50) from the same cohort. The following characteristics were considered: axillary nodal status and tumour size, histologic parameters (tumour type, histologic grade, mitotic rate, tubule formation, nuclear grade, CIS and lymphangio invasion) and expression of several proteins (oestrogen and progesterone receptors, cyclin D1, p53, HER2/neu, E-cadherin). In BRCA1associated tumours receptors for oestrogen and progesterone were expressed less frequently (respectively P= 0.001 and P= 0.002) than in controls, which is in line with findings from other studies. Other differences were also in accordance with findings from other studies, although not statistically significant. We conclude that the features of BRCA1 associated tumours detected in a hospital-based series of breast cancer patients not selected for family history of age at diagnosis are similar to tumours in cases selected for family history or age at diagnosis. © 2001 Cancer Research Campaign http://www.bjcancer.com
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References
Armes JE, Egan AJ, Southey MC, Dite GS, McCredie MRE, Giles GG, Hopper JL and Venter DJ (1998) The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and withoutBRCA1orBRCA2germline mutations: a population-based study. Cancer 83: 2335–2345
Armes JE, Trute L, White D, Southey MC, Hammet F, Tesoriero A, Hutchins A-M, Dite GS, McCredie MRE, Giles GG, Hopper JL and Venter DJ (1999) Distinct molecular pathogeneses of early-onset breast cancers inBRCA1andBRCA2mutations carriers: a population-based study. Cancer Research 59: 2011–2017
Brown DL, Cole BF and Arrick BA (1999) RE: Multifactorial analysis of differences between sporadic breast cancers and cancers involvingBRCA1andBRCA2mutations. J Natl Cancer Inst 91: 90–91
Cattoretti G, Pileri S, Parravicini C, Becker MH, Poggi S, Bifulco C, Key G, D'Amato L, Sabattini E and Feudale E (1993) Antigen unmasking on formalin-fixed, paraffin-embedded tissue sections. J Pathol 171: 83–98
Crook T, Crossland S, Crompton MR, Osin P and Gusterson BA (1997) p 53 mutations inBRCA1-associated familial breast cancer. Lancet 350: 638–639
Eisinger F, Stoppa-Lyonnet D, Longy M, Kerangueven F, Noguchi T, Bailly C, Vincent-Salomon A, Jacquemier J, Birnbaum J and Sobol HI (1996) Germline mutation atBRCA1affects the histoprognostic grade in hereditary breast cancer. Cancer Res 56: 471–474
Eisinger F, Jacquemier J, Charafe-Jauffret E, Rio M-R, Birnbaum D and Sobol H (1999) More about: Multifactorial analysis of differences between sporadic breast cancers and cancers involvingBRCA1andBRCA2mutations. J Natl Cancer Inst 91: 1421–1422
Elston CW and Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19: 403–410
Jacquemier J, Eisinger F, Nogues C, Sun ZZ, Guinebretiere JM, Peyrat JP, Geneix J, Lidereau R, Birnbaum D and Sobol H (1999) Histological type and syncytial growth pattern affect E-cadherin expression in a multifactorial analysis of a combined panel of sporadic andBRCA1-associated breast cancers. Int J Cancer 83: 45–49
Johannsson OT, Idvall I, Anderson C, Borg A, Barakardóttir RB, Egilsson V and Olsson H (1997) Tumour biological features ofBRCA1-induced breast and ovarian cancer. Eur J Cancer 33: 362–371
Karp SE, Tonin PN, Bégin LR, Martinez JJ, Zhang JC, Pollak MN and Foulkes WD (1997) Influence ofBRCA1mutations on nuclear grade and oestrogen receptor status of breast carcinoma in Ashkenazi Jewish women. Cancer 80: 435–441
Lakhani SR (1997) Breast Cancer Linkage Consortium. Pathology of familial breast cancer: differences between breast cancers in carriers ofBRCA1orBRCA2mutations and sporadic cases. Lancet 349: 1505–1510
Lakhani SR, Jacquemier J, Sloane JP, Gusterson BA, Anderson TJ, Van de Vijver MJ, Farid LM, Venter D, Antoniou A, Storfer-Isser A, Smyth E, Steel CM, Haites N, Scott RJ, Goldgar D, Neuhausen S, Daly PA, Ormiston W, McManus R, Scherneck S, Ponder BA, Ford D, Peto J, Stoppa-Lyonnet D and Easton DF (1998) Multifactorial analysis of differences between sporadic breast cancers and cancers involvingBRCA1andBRCA2mutations. J Natl Cancer Inst 90: 1138–1145
Lidereau R, Eisinger F, Champeme MH, Nogues C, Bieche I, Birnbaum D, Pallud C, Jacquemier J and Sobol H (2000) Major improvement in the efficacy ofBRCA1mutation screening using morphoclinical features of breast cancer. Cancer Res 60: 1206–1210
Loman N, Johannsson O, Bendahl PO, Borg A, Ferno M and Olsson H (1998) Steroid receptors in hereditary breast carcinomas associated with BRCA1 or BRCA2 mutations or unknown susceptibility genes. Cancer 83: 310–319
Lynch BJ, Holden JA, Buys SS, Neuhausen SL and Gaffney DK (1998) Pathobiologic characteristics of hereditary breast cancer. Hum Pathol 29: 1140–1144
Marcus JN, Watson P, Page DL, Narod SA, Lenoir GM, Tonin P, Linder-Stephenson L, Salerno G, Conway TA and Lynch HT (1996) Hereditary breast cancer: pathobiology, prognosis, andBRCA1andBRCA2gene linkage. Cancer 77: 697–709
Millar SA, Dykes DD and Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16: 1215
Papelard H, De Bock GH, Van Eijk R, Vliet Vlieland TPM, Cornelisse CJ, Devilee P and Tollenaar RAEM (2000) Preyalence ofBRCA1in a hospital-based population of Dutch breast cancer patients. Br J Cancer 83: 719–724
Petrij-Bosch A, Peelen T, Van Vliet M, Van Eijk R, Olmer R, Drusedau M, Hogervorst FBL, Hageman S, Arts PJW, Ligtenberg MJL, Meijers-Heijboer H, Klijn JGM, Vasen HFA, Cornelisse CJ, Van't Veer LJ, Bakker E, Van Ommen G-JB and Devilee P (1997) BRCA1genomic deletions are major founder mutations in Dutch breast cancer patients. Nat Genet 17: 341–345
Philips KA, Andrulise IL and Goodwin PJ (1999) Breast carcinomas arising in carriers of mutations inBRCA1orBRCA2: are they prognostic different?. J Clin Oncol 17: 3653–3663
Philips KA, Nichol K and Ozcelik H (1999) Frequency of p53 mutations in breast carcinomas of Ashkenazi JewishBRCA1mutation carriers. J Natl Cancer Inst 91: 469–473
Robson M, Gilewski T, Haas B, Levin D, Borgen P, Rajan P, Hirschaut Y, Pressman P, Rosen PP, Lesser ML, Norton L and Offit K (1998) BRCA-associated breast cancer in young women. J Clin Oncol 16: 1642–1649
Shuber AP, Grondin VJ and Klinger KW (1995) A simplified procedure for developing multiplex PCRs. Genome Res 5: 488–493
Van de Vijver MJ, Peterse JL, Mooi WJ, Wisman P, Lomans J, Dalesio O and Nusse R (1988) Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer. N Engl J Med 319: 1239–1245
Verhoog LC, Brekelmans CT, Seynaeve C, Van den Bosch LMC, Dahmen G, Van Geel AN, Tilanus-Linthorst MMA, Bartels CCM, Wagner A, Van den Ouweland A, Devilee P, Meijers-Heijboer EJ and Klijn JGM (1998) Survival and tumour characteristics of breast-cancer patients with germline mutations ofBRCA1. Lancet 351: 316–321
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Bock, G., Tollenaar, R., Papelard, H. et al. Clinical and pathological features of BRCA1 associated carcinomas in a hospital-based sample of Dutch breast cancer patients. Br J Cancer 85, 1347–1350 (2001). https://doi.org/10.1054/bjoc.2001.2103
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DOI: https://doi.org/10.1054/bjoc.2001.2103
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