Summary
The relationships between acute myeloid leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic myeloid leukaemia (CML) and refractory anaemia with excess of blasts (RAEB) and human herpes virus (HHV)-6 antibody level were investigated in a multicentre case-control study. An association between increased HHV-6 seropositivity and geometric mean titre ratio with AML was shown: P for trend = 0.022, adjusted odds ratio 1.20, 95% confidence interval 1.07–1.33 respectively. No association was found between HHV-6 and ALL, CML or RAEB.
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The members of GIMEMA are as follows: R Colombini (Istituto di Ematologia Seragnoli, Bologna); S Merante (Divisione di Ematologia, Pavia); A Capobianchi, S Capucci, A Vitale (Dipartimento di Biotecnologie Cellulari e Ematologia, Roma)
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Gentile, G., Mele, A., Ragona, G. et al. Human herpes virus-6 seroprevalence and leukaemias: a case-control study. Br J Cancer 80, 1103–1106 (1999). https://doi.org/10.1038/sj.bjc.6690471
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DOI: https://doi.org/10.1038/sj.bjc.6690471
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