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A brain-derived neurotrophic factor (BDNF) haplotype is associated with antidepressant treatment outcome in mood disorders

The Pharmacogenomics Journal volume 8, pages 101–112 (2008)Cite this article

Abstract

Brain-derived neurotrophic factor (BDNF) has been studied extensively in relation to the susceptibility to mood disorders (MD), although it remains to be clarified whether BDNF is a susceptibility locus for MD phenotypes, including therapeutic response to antidepressants. We have performed a single-marker and haplotype association study of eight TagSNPs polymorphisms in the genomic region containing the BDNF gene in 342 control subjects and 374 patients with MD, and have tested the association with antidepressant treatment outcome. None of the eight single nucleotide polymorphisms (TagSNPs) was significantly associated with MD phenotype after Bonferroni correction. In the single-marker analysis, a SNP was found to be associated with the patient's state of ‘remitter’ after adequate trial with a single antidepressant phenotype (odds ratio (OR)=2.95; P=0.0025). We also identified a haplotype associated with this phenotype. This study supports the implication of BDNF in antidepressant treatment outcome in MD, with specific association with 5′ upstream region of BDNF gene.

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Acknowledgements

The authors thank all the study participants and the staff from Department of Psychiatry of ‘Hospital Universitari de Bellvitge’, who have collaborated to obtain the sample of this study. This research project was supported by the Psychiatry Genetics Network (G03/184) funded by the ‘Instituto de Salud Carlos III-FIS’, project PI041257 funded by the ‘Instituto Carlos III-FIS’, project PI052307 funded by the ‘Instituto de Salud Carlos III-FIS’, the National Center of Genotyping-CEGEN funded by ‘Genoma España’: the CIBERESP (CB06/02/0058) and the RETICS RD06/0011(REM-TAP Network) supported by the Spanish Ministry of Health, Instituto de Salud Carlos III-FIS. VS was funded by IDIBELL (‘Institut d’Investigació Biomèdica de Bellvitge'), the Department of Universities, Research and Information Society (2005SGR00008).

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  1. M Gratacòs and V Soria: These authors contributed equally to this work.

Authors and Affiliations

  1. Genes and Disease Program, and CeGen Barcelona Genotyping Node, Center for Genomic Regulation (CRG), Barcelona, Spain

    M Gratacòs, J R González, M Bayés, R de Cid & X Estivill

  2. Psychiatry Department, Mood Disorders Clinical and Research Unit, Hospital Universitari de Bellvitge, Feixa Llarga s/n, L'Hospitalet de Llobregat, Barcelona, Spain

    V Soria, M Urretavizcaya, J M Crespo, J M Menchón & J Vallejo

  3. Department of Life Sciences, Pompeu Fabra University, Barcelona, Spain

    X Estivill

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Gratacòs, M., Soria, V., Urretavizcaya, M. et al. A brain-derived neurotrophic factor (BDNF) haplotype is associated with antidepressant treatment outcome in mood disorders. Pharmacogenomics J 8, 101–112 (2008). https://doi.org/10.1038/sj.tpj.6500460

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