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Pharmacogenetics Research Network and Knowledge Base Fourth Scientific Meeting

The Pharmacogenomics Journal volume 4, pages 359–361 (2004)Cite this article

Now in its fifth year, the Pharmacogenetics Research Network and Knowledge Base (PGRN) is a multidisciplinary, collaborative research effort dedicated to probing relationships between genetic variation and interindividual differences in drug responses. The overarching goal of the program is to identify links between genotypic and phenotypic information, forging new knowledge about drug response and human physiology. The diversity of scientific interest spanning the group creates unique challenges but affords the opportunity for cross-fertilization of hypothesis generation, data analysis, and integrative exercises (eg creating biochemical/metabolic pathways to describe drug–gene–disease interactions). A guiding principle has been to create an open access resource of broad applicability to the scientific community.

In recent years, research on the interindividual variation of drug response has undergone rapid change, in large part due to the arrival of the genomic age. Distinguishing the terms pharmacogenetics and pharmacogenomics may be a subjective exercise that hinges on pragmatism. Furthering this notion, Urs Meyer (University of Basel) presented his view of the role pharmacogenomics currently plays in industrial drug discovery. While pharmacogenetics may be thought of as ‘one drug, many genomes’, pharmacogenomics could be better defined as ‘many drugs, one genome’. Pharmacogenomics encompasses the study of the effect of drugs on gene expression, and a key challenge remains analyzing the complex genomic and proteomic effects of drugs on human metabolism.

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Acknowledgements

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  1. Office of Communications and Public Liaison, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, USA

    A F Davis

  2. Division of Pharmacology, Physiology, and Biological Chemistry, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, USA

    R M Long

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  1. A F Davis
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  2. R M Long
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Correspondence to R M Long.

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None declared.

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Davis, A., Long, R. Pharmacogenetics Research Network and Knowledge Base Fourth Scientific Meeting. Pharmacogenomics J 4, 359–361 (2004). https://doi.org/10.1038/sj.tpj.6500277

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