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Polymorphisms in the ABC drug transporter gene MDR1

The Pharmacogenomics Journal volume 1, pages 59–64 (2001)Cite this article

Abstract

In addition to genetically variable metabolic enzymes such as Cyp p450 proteins, blood and tissue levels of many drugs are influenced by controlled transport across compartmental boundaries. Major determinants in these transport processes are ATP-dependent efflux pumps such as P-glycoprotein and related proteins (eg MRPs), which can influence the bioavailability and CNS concentrations, as well as disposition of drugs. In addition to its recognized role in the development of multiple chemotherapy resistances, experimental evidence for the relevant influence of the MDR1 gene encoded P-glycoprotein, on the pharmacology of many other drugs has been gathered by the analyses of knockout mice, as well as in clinical studies. Recently, functional genetic polymorphisms in the MDR1 gene have been identified which influence the distribution and bioavailability of PGP substrates.

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Acknowledgements

This work is supported by a BMBF grant No. 01GG9846 from the German Ministry for Education, Science, Research and Technology.

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  1. Epidauros Biotechnology, Bernried, Germany

    U Brinkmann

  2. Dr Margarete Fischer Bosch Institute for Clinical Pharmacology, Stuttgart, Germany and Institute for Clinical Pharmacology, University of Tübingen, Germany

    M Eichelbaum

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Brinkmann, U., Eichelbaum, M. Polymorphisms in the ABC drug transporter gene MDR1. Pharmacogenomics J 1, 59–64 (2001). https://doi.org/10.1038/sj.tpj.6500001

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