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A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population

Genes & Immunity volume 7, pages 606–608 (2006)Cite this article

Abstract

Association between Myosin IXB (MYO9B) gene polymorphisms and celiac disease (CD) was recently detected by a case–control association study in the Dutch, but not confirmed in the British and Swedish/Norwegian populations. We tested the association between CD and the three most associated single nucleotide polymorphisms (SNPs) in the Dutch study by the transmission disequilibrium test in the Italian population. A total of 252 pediatric patients and 504 parents were genotyped. No transmission distortion was detected either for the single SNPs or for their haplotypic combinations. Control allele frequencies, calculated from untransmitted alleles, were significantly different from those of the Dutch control population. Conversely, allele frequencies were very similar in Italian, British, Swedish/Norwegian and Dutch patients. In conclusion, MYO9B is not involved in CD susceptibility in the Italian population. The difference with the Dutch result might be explained by an imperfect selection of the Dutch controls.

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Acknowledgements

This work was supported by ELFID (European Laboratory for Food Induced Disease), the Italian Ministero della Salute (Project 2000, no. 0AB/F), the Italian Ministero dell'Istruzione, Università e Ricerca (MIUR-PRIN no. MM06 187812) and by CARIPLO and ‘Compagnia S Paolo’ foundations. MM was supported by a fellowship from Regione Piemonte. We are grateful to the patients and their parents.

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Authors and Affiliations

  1. Department of Medical Sciences, University of Eastern Piedmont and Interdisciplinary Research Center for Autoimmune Diseases (IRCAD), Novara, Italy

    M Giordano, M Mellai, E Bolognesi & P Momigliano-Richiardi

  2. Department of Paediatrics, University of Naples Federico II and European Laboratory of Food Induced Disease (ELFID), Naples, Italy

    C Marano, M G Limongelli & L Greco

  3. INSERM U535, University of Paris XI, Hôpital Paul Brousse, Villejuif, France

    F Clerget-Darpoux

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  1. M Giordano
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  2. C Marano
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  3. M Mellai
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  4. M G Limongelli
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  5. E Bolognesi
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  6. F Clerget-Darpoux
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  7. P Momigliano-Richiardi
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  8. L Greco
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Correspondence to M Giordano.

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Giordano, M., Marano, C., Mellai, M. et al. A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population. Genes Immun 7, 606–608 (2006). https://doi.org/10.1038/sj.gene.6364331

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  • DOI: https://doi.org/10.1038/sj.gene.6364331

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