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Evidence for linkage to and association with type 1 diabetes at the 3q21 region in the Finnish population

Genes & Immunity volume 7, pages 69–72 (2006)Cite this article

Abstract

IDDM9-region on chromosome 3q has shown suggestive evidence for linkage to type 1 diabetes in some but not all genome scans. We analyzed 22 microsatellite markers in 121 Finnish type 1 diabetes multiplex families across the IDDM9-region. Two-point maximum LOD scores of 3.4 and 2.5 were detected with markers D3S1589 and D3S3606, respectively. Two markers were further tested for association using the transmission disequilibrium test in 384 Finnish type 1 diabetes simplex families. Marker AFM203wd10 showed association with type 1 diabetes (P=0.0002 for allele R16). Association was present in families with children carrying the HphI-23 AA risk genotype at IDDM2 but not in families with children carrying protective AT or TT genotypes implying interaction between the two loci. Our data gives credence to earlier findings of linkage in this region and suggests a location for a polymorphism affecting type 1 diabetes susceptibility in the area surrounding AFM203wd10.

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Acknowledgements

This study was supported by Juvenile Diabetes Research Foundation (JDRF), EFSD/JDRF/Novo Nordisk Foundation Focused Research Grant for Type 1 Diabetes, Novo Nordisk Foundation, Foundation for Diabetes Research in Finland, Turku University Central Hospital and the Academy of Finland.

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Authors and Affiliations

  1. JDRF Centre for Prevention of Type 1 Diabetes in Finland and Department of Virology, University of Turku, Turku, Finland

    A-P Laine, H Turpeinen, R Hermann & J Ilonen

  2. JDRF Centre for Prevention of Type 1 Diabetes in Finland and Department of Paediatrics, University of Turku, Turku, Finland

    O Simell

  3. Department of Paediatrics, University of Oulu, Oulu, Finland

    R Veijola

  4. Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland

    M Knip

  5. Department of Paediatrics, Tampere University Hospital, Tampere, Finland

    M Knip

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  1. A-P Laine
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  2. H Turpeinen
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  3. R Veijola
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  4. R Hermann
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  5. O Simell
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  6. M Knip
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  7. J Ilonen
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Correspondence to A-P Laine.

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Laine, AP., Turpeinen, H., Veijola, R. et al. Evidence for linkage to and association with type 1 diabetes at the 3q21 region in the Finnish population. Genes Immun 7, 69–72 (2006). https://doi.org/10.1038/sj.gene.6364269

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  • DOI: https://doi.org/10.1038/sj.gene.6364269

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