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Interleukin 10 polymorphisms in ankylosing spondylitis

Genes & Immunity volume 4, pages 74–76 (2003)Cite this article

Abstract

Genetic polymorphisms of the IL10 promoter region have been implicated in many autoimmune diseases, including seronegative spondyloarthropathies. We studied three SNPs (IL10–1087, −824, and −597) and two microsatellites (IL10R and IL10G) lying within the promoter region of IL10 for association with susceptibility to and clinical manifestations of ankylosing spondylitis (AS), a common form of spondyloarthritis. Four hundred and sixty-eight individuals from 182 Finnish families affected with AS were studied. No association between individual IL10 promoter region polymorphisms or marker haplotype was observed with susceptibility to AS, but weak association was noted between the IL10–597 and −824 SNPs and age of disease onset (P=0.01 for each SNP). The IL10.G4 allele was associated with BASFI (corrected for disease duration) (P=0.03). We conclude that IL10 promoter polymorphisms have no significant effect on susceptibility to AS, but may play a minor role in determining age of disease onset and disease severity.

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Authors and Affiliations

  1. Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, UK

    V Goedecke, A M Crane, E Jaakkola, J Wilson, B P Wordsworth & M A Brown

  2. Johannes-Gutenberg-Universität Mainz, Langenbeckstrasse 1, Mainz, Germany

    W Kaluza

  3. Rheumatism Foundation Hospital, Heinola, Finland

    K Laiho, M Kauppi & K Kaarela

  4. Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA

    D E Weeks

  5. National Public Health Institute, Helsinki, Finland

    J Tuomilehto

  6. Department of Public Health, University of Helskinki, Helskinki, Finland

    J Tuomilehto

Authors
  1. V Goedecke
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  2. A M Crane
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  3. E Jaakkola
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  4. W Kaluza
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  5. K Laiho
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  6. D E Weeks
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  7. J Wilson
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  8. M Kauppi
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  9. K Kaarela
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  10. J Tuomilehto
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  11. B P Wordsworth
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  12. M A Brown
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Correspondence to M A Brown.

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Goedecke, V., Crane, A., Jaakkola, E. et al. Interleukin 10 polymorphisms in ankylosing spondylitis. Genes Immun 4, 74–76 (2003). https://doi.org/10.1038/sj.gene.6363930

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  • DOI: https://doi.org/10.1038/sj.gene.6363930

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