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Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)

Genes & Immunity volume 3, pages 295–298 (2002)Cite this article

Abstract

The CCR5-Δ32 genotype is known to influence HIV-1 transmission and disease. We genotyped 1301 US women of various races/ethnicities participating in the HIV Epidemiologic Research Study. None was homozygous for CCR5-Δ32. The distribution of heterozygotes was similar in HIV-1 infected and uninfected women. Thirty-seven (11.8%) white, 28 (3.7%) blacks/African Americans (AA), seven (3.3%) Hispanics/Latinas, and one (6.6%) other race/ethnicity were heterozygous. The frequency of heterozygotes differed among sites for all races combined (P = 0.001). More heterozygotes were found in AA women in Rhode Island (8.9%) than in the other sites (3.1%) (P = 0.02), while heterozygosity in white women was most common in Maryland (28.6%) (P = 0.025). These regional differences could be accounted for by racial admixture in AAs, but not in whites. Regional variations should be considered when studying host genetic factors and HIV-1 in US populations.

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References

  1. Samson M, Libert F, Doranz BJ et al. Resistance to HIV-1infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene Nature 1996 382: 722–725

    Article  CAS  Google Scholar 

  2. Liu R, Paxton WA, Choe S et al. Homozygous defect in HIV-1 co-receptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection Cell 1996 86: 367–377

    Article  CAS  Google Scholar 

  3. Dean M, Carrington M, Winkler C et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion of the CKR5 structural gene Science 1996 273: 1856–1862

    Article  CAS  Google Scholar 

  4. Huang Y, Paxton WA, Wolinsky SM et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression Nat Med 1996 2: 1240–1243

    Article  CAS  Google Scholar 

  5. Michael NL, Chang G, Louie LG et al. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression Nat Med 1997 3: 338–340

    Article  CAS  Google Scholar 

  6. Eugen-Olsen J, Iversen AK, Garred P et al. Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals AIDS 1997 11: 305–310

    Article  CAS  Google Scholar 

  7. Smith DK, Warren DL, Vlahov D et al. Design and baseline participant characteristics of the human immunoldeficiency virus (HER) study: a prospective cohort study of human immunodeficiency virus infection in US women Am J Epidemiol 1997 146: 459–469

    Article  CAS  Google Scholar 

  8. Solomon L, Styein M, Flynn C et al. Health services use by urban women with or at risk for HIV-1 infection: the HIV Epidemiology Research Study (HERS) J Acquir Immune Defic Syndr Hum Retrovirol 1998 17: 253–261

    Article  CAS  Google Scholar 

  9. Guo SW, Thompson EA . Performing the exact test of Hardy-Weinberg proportion for multiple alleles Biometrics 1992 48: 361–372

    Article  CAS  Google Scholar 

  10. Zimmerman PA, Bucklerwhite A, Alkhatib G et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5 – studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk Mol Med 1997 3: 23–36

    Article  CAS  Google Scholar 

  11. O’Brien TR, Padian NS, Hodge T et al. CCR5 genotype and sexual transmission of HIV-1 AIDS 1998 12: 444–445

    PubMed  Google Scholar 

  12. Burger H, Tarwater P, Kleeberger C et al. CCR5 genotype and susceptibility to transmission of HIV-1 to women. Abstract No.WePeA3998 XIIIth International AIDS Conference, Durban, South Africa, 9^14 July 2000

  13. Williams RC, Steinberg AG, Knowler WC, Pettitt DJ . Gm 3; 5, 13, 14 and stated-admixture: independent estimates of admixture in American Indians Am J Hum Genet 1986 39: 409–413

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Kokkotou E, Philippon V, Gueye-Ndiaye A et al. Role of the CCR532 allele in resistance to HIV-1 infection in West Africa J Hum Virol 1998 1: 469–474

    CAS  PubMed  Google Scholar 

  15. Elharti E, Elaouad R, Simons M et al. Frequency of the CCR5 Δ32 allele in the Moroccan population AIDS Res Hum Retrov 2000 16: 87–89

    Article  CAS  Google Scholar 

  16. Martinson JJ, Chapman NH, Rees DC, Liu YT, Clegg JB . Global distribution of the CCR5 gene 32-basepair deletion Nat Gen 1997 16: 100–103

    Article  CAS  Google Scholar 

  17. Lu C, Williams T, Makuwa M et al. Analysis of genetic polymorphism of the HIV-coreceptor (CCR5) locus in a Gabonese population (abstract 044A297). Presented at Xth International Conference on AIDS and STD in Africa, Abidjan, December 1997

  18. Stephens JC, Reich DE, Goldstein DB et al. Dating the origin of the CCR5-Delta 32 AIDS-resistance allele by the coalescence of haplotypes Am J Hum Genet 1998 62: 1507–1515

    Article  CAS  Google Scholar 

  19. Lucotte G, Mercier G . Distribution of the CCR5 gene 32-bp deletion in Europe J Acquir Immune Defic Syndr Hum Retrovirol 1998 19: 174–177

    Article  CAS  Google Scholar 

  20. Acton RT, Harman L, Go RCP, Tseng ML, Bias W . Comparison of HLA phenotypes among African Americans from Alabama, Maryland, and North Carolina Transplant Proc 1993 25: 2404–2407

    CAS  PubMed  Google Scholar 

  21. Terasaki PI, Gjertson DW (eds). HLA 1997 UCLA Tissue Typing Laboratory: Los Angeles 1997 pp 317–323

    Google Scholar 

  22. Gjertson DW, Terasaki PI (eds). HLA 1998 American Society of Histocompatibility and Immunogenetics: Lenexa 1998 pp 231–234

    Google Scholar 

  23. Terasaki PI, Gjertson DW (eds). HLA 1997 UCLA Tissue Typing Laboratory: Los Angeles 1997 pp 336–346

    Google Scholar 

  24. National Center for HIV, STD and TB prevention. Divisions of HIV/AIDS Prevention. HIV/AIDS among US Women: minority and young women at continuing risk Centers for Disease Control and Prevention. Atlanta, GA http://www.cdc.gov/hiv/pubs/facts/women.htm

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Authors and Affiliations

  1. Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA

    M V Downer, T Hodge, S H Qari & J M McNicholl

  2. Division of HIV/AIDS Prevention – Surveillance and Epidemiology, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA

    D K Smith & L I Gardner

  3. Division of Infectious Disease, School of Medicine, Wayne State University, Detroit, MI, USA

    P Schuman

  4. Infectious Disease Division, Department of Medicine, Brown University, Providence, RI, USA

    K H Mayer

  5. Departments of Medicine and Epidemiology and Social Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA

    R S Klein

  6. Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD, USA

    D Vlahov

Authors
  1. M V Downer
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  2. T Hodge
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  3. D K Smith
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  4. S H Qari
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  5. P Schuman
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  6. K H Mayer
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  7. R S Klein
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  8. D Vlahov
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  9. L I Gardner
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  10. J M McNicholl
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Corresponding author

Correspondence to J M McNicholl.

Additional information

MVD was supported by a CDC/ATPM Career Development Award Fellowship.

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Downer, M., Hodge, T., Smith, D. et al. Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS). Genes Immun 3, 295–298 (2002). https://doi.org/10.1038/sj.gene.6363884

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  • DOI: https://doi.org/10.1038/sj.gene.6363884

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