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A genome-wide linkage analysis of orchard grass-sensitive childhood seasonal allergic rhinitis in Japanese families

Genes & Immunity volume 3, pages 9–13 (2002)Cite this article

Abstract

Seasonal allergic rhinitis (SAR) is an inflammatory disease of the nose and eyes that follows sensitization to air-born pollens. We conducted a genome-wide linkage screening of 48 Japanese families (188 members) with orchard grass (OG)-sensitive SAR children (67 affected sib-pairs) in a farming community in central Japan where OG was planted for apple farming and OG pollen is a major cause of SAR. We used the GENEHUNTER program to performed nonparametric multipoint linkage analysis for OG-sensitive SAR as a qualitative trait and for log total serum IgE levels and OG-RAST IgE levels as quantitative traits. Genotyping data of 400 microsatellite markers suggested linkage of SAR to chromosomes 1p36.2, 4q13.3, and 9q34.3 (P < 0.001), linkage of serum total IgE levels to 3p24.1, 5q33.1, 12p13.1, and 12q24.2 (P < 0.001), and linkage of OG-RAST IgE levels to 4p16.1, 11q14.3, and 16p12.3 (P < 0.001). Weak evidence for linkage of SAR to 5q33.1 was also observed (P = 0.01). All these regions, with the exception of 9q34.3, have been previously reported to be linked to asthma and/or atopy. These data suggest that, although loci linked to SAR are likely to be common to asthma, a strong contribution by specific gene(s) to OG-sensitive SAR is unlikely.

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Authors and Affiliations

  1. Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan

    Y Yokouchi, E Noguchi, J Nakayama, T Ohtsuki, M Kamioka, K Yamakawa-Kobayashi, S Ito, Y Nukaga, H Hamaguchi & T Arinami

  2. Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan

    Y Yokouchi, M Shibasaki, E Noguchi, J Nakayama, K Takeda, K Ichikawa & A Matsui

  3. Department of Dermatology, University of Tsukuba, Tsukuba, Japan

    Y Nukaga

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  1. Y Yokouchi
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  2. M Shibasaki
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Correspondence to T Arinami.

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This study was supported by grants from Ministry of Education, Culture, Sports, Science and Technology.

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Yokouchi, Y., Shibasaki, M., Noguchi, E. et al. A genome-wide linkage analysis of orchard grass-sensitive childhood seasonal allergic rhinitis in Japanese families. Genes Immun 3, 9–13 (2002). https://doi.org/10.1038/sj.gene.6363815

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  • DOI: https://doi.org/10.1038/sj.gene.6363815

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