Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Full Paper
  • Published:

Polymorphisms of Fcγ-receptors RIIa, RIIIa, and RIIIb in patients with adult periodontal diseases

Genes & Immunity volume 2, pages 258–262 (2001)Cite this article

Abstract

Polymorphisms influencing the binding affinity between the Fcγ receptors and IgG of different subclasses are thought to be of importance in the individual susceptibility to infections with Gram-negative bacteria contributing to periodontal disease. One hundred and fifty-four Caucasian subjects were clinically and radiographically examined for their periodontal status and genotyped for their allelic pattern of FcγRIIa, FcγRIIIa, and FcγIIIb polymorphism. In assessing periodontitis according to mean probing depth and attachment loss, no differences were found in allele frequencies or combined allotypes between the subjects with mild or moderate and those with severe signs of periodontitis. However, the extent and severity of bone loss were significantly associated with the genotype of the receptor FcγRIIIa. An increased risk of severe bone destruction was observed in individuals carrying the FcγRIIIa-VV genotype (OR = 5.3; 95% CI 1.4–26.2). FcγRIIIb is in linkage disequilibrium with FcγRIIIa. Hence it is also related to periodontal disease. There is no indication of an association between the polymorphism of FcγRIIa and periodontitis. The results are evidence that the FcγRIIIa genotype coding for the high affinity receptor imposes an additional risk of bone loss as does the FcγRIIIb genotype coding for the low affinity receptor.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Rascu A, Repp R, Westerdaal NAC, Kalden JR, van de Winkel JGJ Clinical relevance of Fcγ receptor polymorphisms Ann NY Acad Sci 1997 815 282–295

    Article  CAS  Google Scholar 

  2. Warmerdam PAM, van de Winkel JGJ, Vlug A, Westerdaal NAC, Capel PAJ A single amino acid in the second Ig-like domain of the human Fcγ receptor II is critical for human IgG2 binding J Immunol 1991 147 1338–1343

    CAS  PubMed  Google Scholar 

  3. Beck JD Risk revisited Comm Dent Oral Epidemiol 1998 26 220–225

    Article  CAS  Google Scholar 

  4. Beck JD, Slade GD Epidemiology of periodontal diseases Curr Opin Periodontol 1996 3 3–9

    CAS  PubMed  Google Scholar 

  5. Hart T, Kornman KS Genetic factors in the pathogenesis of periodontitis Periodontology-2000 1998 14 202–215

    Article  Google Scholar 

  6. Landi L, Amar S, Polins AS, van Dyke TE Host mechanisms in the pathogenesis of periodontal disease Curr Opin Periodontol 1997 4 3–10

    CAS  PubMed  Google Scholar 

  7. Michalowicz BS Genetic and heritable risk factors in periodontal disease J Periodontol 1994 65 479–488

    Article  CAS  Google Scholar 

  8. Lehrnbecher T, Foster CB, Zhu S et al Variant genotypes of the low-affinity Fcγ receptors in two control populations and a review of low-affinity Fcγ receptors polymorphisms in control and disease populations Blood 1999 94 4220–4232

    CAS  PubMed  Google Scholar 

  9. Tonetti MS, Mombelli A Early-onset periodontitis Ann Periodontol 1999 4 39–53

    Article  CAS  Google Scholar 

  10. Streckfus CF, Parsell DE, Streckfus JE, Pennington W, Johnson RB. Relationship between oral alveolar bone loss and aging among African-American and Caucasian individuals Gerontology 1999 45 110–114

    Article  CAS  Google Scholar 

  11. Afar B, Engel D, Clark EA Activated lymphocyte subsets in adult periodontitis J Periodont Res 1992 27 126–133

    Article  CAS  Google Scholar 

  12. Sugita N, Suzuki T, Yoshie H, Yoshida N, Adachi M, Hara K Differential expression of CR3, Fc epsilon RII and Fc gamma RIII on polymorphonuclear leukocytes in gingival crevicular fluid J Periodontal Res 1993 28 363–372

    Article  CAS  Google Scholar 

  13. Wu J, Edberg JC, Redecha PB et al A novel polymorphism of FcγRIIIa (CD16) alters receptor function and predisposes to autoimmune disease J Clin Invest 1997 100 1059–1070

    Article  CAS  Google Scholar 

  14. Sulica A, Metes D, Gherman M, Whiteside TL, Herberman RB Divergent effects of FcγRIIIA ligands on the functional activities of human natural killer cells in vitro Eur J Immunol 1996 26 1199–1203

    Article  CAS  Google Scholar 

  15. Lerner UH, Modeer T, Krekmanova L, Claesson R, Rasmussen L Gingival crevicular fluid from patients with periodontitis contains bone resorbing activity Eur J Oral Sci 1998 106 778–787

    Article  CAS  Google Scholar 

  16. Matsumoto A, Anan H, Maeda K An immunohistochemical study of the behavior of cells expressing interleukin-1 alpha and interleukin-1 beta within experimentally induced periapical lesions in rats J Endodontics 1998 24 811–816

    Article  CAS  Google Scholar 

  17. Kornman KS, di Giovine FS Genetic variations in cytokine expression: a risk factor for severity of adult periodontitis Ann Periodontol 1998 3 327–338

    Article  CAS  Google Scholar 

  18. Wilson ME, Kalmar JR FcγRIIa (CD32): a potential marker defining susceptibility to localized juvenile periodontitis J Periodontol 1996 67 323–331

    Article  Google Scholar 

  19. Wilson ME, Bronson PM, Hamilton RG Immunoglobulin G2 antibodies promote neutrophil killing of Actinobacillus actinomycetemcomitans Infect Immun 1995 63 1070–1075

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Colombo AP, Eftimiadi C, Haffajee AD, Cugini MA, Socransky SS Serum IgG2 level, Gm(23) allotype and FcγRIIa and FcγRIIIb receptors in refractory periodontal disease J Clin Periodontol 1998 25 465–474

    Article  CAS  Google Scholar 

  21. Sugita N, Yamamoto K, Kobayashi T et al Relevance of Fc gamma RIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients Clin Exp Immunol 1999 117 350–354

    Article  CAS  Google Scholar 

  22. Kobayashi T, Westerdaal NA, Miyazaki A et al Relevance of immunoglobulin G Fc receptor polymorphism to recurrence of adult periodontitis in Japanese patients Infect Immun 1997 65 3565–3560

    Google Scholar 

  23. Kobayashi T, van der Pol WL, van de Winkel JG et al Relevance of IgG receptor IIIb (CD16) polymorphism to handling of Porphyromonas gingivalis: implications for the pathogenesis of adult periodontitis J Periodont Res 2000 35 65–73

    Article  CAS  Google Scholar 

  24. Carlsson LE, Santoso S, Baurichter G et al Heparin-induced thrombocytopenia: new insights into the impact of the FcγRIIa-R-H131 polymorphism Blood 1998 92 1526–1531

    CAS  PubMed  Google Scholar 

  25. Koene HR, Kleijer M, Algra J, Roos D, von dem Borne AEG, de Haas M FcγRIIIa-158V/F polymorphism influences the binding of IgG by NK cell FcγRIIIa, independently of the FcγRIIIa-48L/R/H phenotype Blood 1997 90 1109–1114

    CAS  PubMed  Google Scholar 

  26. DeHaas M, Kleijer M, van Zwieten R, Roos D, von dem Borne AE Neutrophil Fc gamma RIIIb deficiency, nature, and clinical consequences: a study of 21 individuals from 14 families Blood 1995 86 2403–2413

    CAS  Google Scholar 

Download references

Acknowledgements

We wish to thank Mrs Ingrid Geissler and Ms Carmen Blumentritt for skilful technical assistance.

Author information

Authors and Affiliations

  1. Department of Pharmacology, Ernst Moritz Arndt University Greifswald, Germany

    P Meisel

  2. Department of Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald, Germany

    LE Carlsson & A Greinacher

  3. Department of Periodontology, Ernst Moritz Arndt University Greifswald, Germany

    H Sawaf, J Fanghaenel & T Kocher

Authors
  1. P Meisel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. LE Carlsson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H Sawaf
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Fanghaenel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A Greinacher
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T Kocher
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P Meisel.

Additional information

This study was supported by a grant Deutsche Forschungsgemeinschaft DFG Gr 1096/2–3.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Meisel, P., Carlsson, L., Sawaf, H. et al. Polymorphisms of Fcγ-receptors RIIa, RIIIa, and RIIIb in patients with adult periodontal diseases . Genes Immun 2, 258–262 (2001). https://doi.org/10.1038/sj.gene.6363777

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.gene.6363777

Keywords

This article is cited by

Search

Advanced search

Quick links