Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Full Paper
  • Published:

HLA alleles in relation to specific immunity to Liver Stage Antigen-1 from Plasmodium falciparum in Gabon

Abstract

Cellular responses to synthetic peptides from the Liver Stage Antigen-1 (LSA-1) from Plasmodium falciparum were determined in 229 Gabonese children. HLA class I and II typing (by PCR-SSP and -RFLP, respectively) revealed that HLA-A*19, -B*17 (and -B*70), -DRB1*05, -DQA1*0102, -DQB1*0602 and -DPB1*0402 were the most frequent types or alleles at each locus. The DQB1*0201 and DQB1*0301 alleles were present at a higher frequency among IL-6 and IFN-γ responders to the LSA-Rep and LSA-CTL peptides, respectively, and a higher proportion of these responders carriedA*19 or B*53. The DRB1*06 type was positively related to the IL-10 production in response to the LSA-CTL peptide, and responders presented mainly A*2. The specificity A*10 was negatively associated with the cellular response to the LSA-J peptide. These results suggest a degree of genetic regulation of specific immune responses by HLA-A, operating at the pre-erythrocytic stage of development of P. falciparum in this Central African population.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to F Migot-Nabias.

Additional information

This study was partially supported by an INSERM North-South Network grant (No. 94/NS01). The Centre International de Recherches Médicales de Franceville is financially supported by the government of Gabon, Elf Gabon and the Ministère Français des Affaires Etrangères.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Migot-Nabias, F., Luty, A., Minh, T. et al. HLA alleles in relation to specific immunity to Liver Stage Antigen-1 from Plasmodium falciparum in Gabon. Genes Immun 2, 4–10 (2001). https://doi.org/10.1038/sj.gene.6363713

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.gene.6363713

Keywords

This article is cited by

Search

Quick links