Abstract
Recently, genome-wide searches for multiple sclerosis (MS) susceptibility genes have suggested that the chromosome 17q22–q24 region might contain susceptibility genes in two sets of families of different ethnic backgrounds (Finnish and British). Therefore, we decided to test this region in two sets of families of different ethnic backgrounds (American and French), but collected according to the same diagnostic criteria. All lod-score values were non-significant. Moreover, we could exclude that the 17q22–24 region might contain a gene increasing the sibling recurrence risk of MS over 1.4, rendering the existence of such a gene very unlikely, at least in the group of tested families.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 6 digital issues and online access to articles
$119.00 per year
only $19.83 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Consortia
Corresponding author
Additional information
This study was supported by ARSEP, INSERM, APHP (DRC), AFM and PHRC.
Rights and permissions
About this article
Cite this article
Fontaine, B., Cournu, I., Arnaud, I. et al. Chromosome 17q22–q24 and multiple sclerosis genetic susceptibility. Genes Immun 1, 149–150 (1999). https://doi.org/10.1038/sj.gene.6363646
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.gene.6363646