Abstract
Y-chromosomal DNA haplotypes were determined in 74 infertile and 216 control Italian males using eight biallelic markers. A significant difference in haplotype frequency was found, but could be explained by the geographical origins of the samples. The Y chromosome is thus a sensitive marker for population substructuring and may be useful for determining whether two population samples come from a single population, for example in association studies.
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Previderé, C., Stuppia, L., Gatta, V. et al. Y-chromosomal DNA haplotype differences in control and infertile Italian subpopulations. Eur J Hum Genet 7, 733–736 (1999). https://doi.org/10.1038/sj.ejhg.5200359
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DOI: https://doi.org/10.1038/sj.ejhg.5200359
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