Abstract
A second kindred has been identified which supports the previously reported location of DFNB9. Linkage has been established to markers closely linked to DFNB9 which is located on 2p22-p23. The hearing impaired individuals in this highly consanguineous kindred from Eastern Turkey have prelingual profound hearing loss which affects all frequencies. A genetic map of the 2p22-p23 region where DFNB9 resides was generated using marker genotypes available from the CEPH database. All markers were placed on this genetic map using a likelihood ratio criterion of 1000:1. This map suggests that the region for DFNB9 is less than 1.08 cM, 95% confidence interval (0–2.59 cM).
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Leal, S., Apaydin, F., Barnwell, C. et al. A second Middle Eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9. Eur J Hum Genet 6, 341–344 (1998). https://doi.org/10.1038/sj.ejhg.5200201
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DOI: https://doi.org/10.1038/sj.ejhg.5200201