An enzyme that links two metabolic hubs has been found to be upregulated in the fat cells of overweight mice. Inhibition of the gene encoding this enzyme protects mice from diet-induced obesity. See Letter p.258
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References
- 1.
Kraus, D. et al. Nature 508, 258–262 (2014).
- 2.
Ghanta, S., Grossmann, R. E. & Brenner, C. Crit. Rev. Biochem. Mol. Biol. 48, 561–574 (2013).
- 3.
Abel, E. D. et al. Nature 409, 729–733 (2001).
- 4.
Yang, Q. et al. Nature 436, 356–362 (2005).
- 5.
Lee, Y. H. et al. Diabetologia 48, 1776–1783 (2005).
- 6.
Bogan, K. L. & Brenner, C. Annu. Rev. Nutr. 28, 115–130 (2008).
- 7.
Aksoy, S., Szumlanski, C. L. & Weinshilboum, R. M. J. Biol. Chem. 269, 14835–14840 (1994).
- 8.
Lu, S. C. Int. J. Biochem. Cell Biol. 32, 391–395 (2000).
- 9.
Jell, J. et al. J. Biol. Chem. 282, 8404–8413 (2007).
- 10.
Pirinen, E. et al. Mol. Cell. Biol. 27, 4953–4967 (2007).
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Charles Brenner is in the Department of Biochemistry, the Obesity Research Initiative, University of Iowa, Iowa City, Iowa 52242, USA.
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