Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Infection biology

Cheats never prosper

Subjects

Fast-growing 'defector mutants' can threaten the success of a bacterial infection. But one bacterial species prevails over these cheats by forming a subpopulation that has shut down expression of virulence genes. See Letter p.353

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Bistability prevents the rise of mutant defectors.

References

  1. Diard, M. et al. Nature 494, 353–356 (2013).

    Article  ADS  CAS  Google Scholar 

  2. West, S. A., Griffin, A. S., Gardner, A. & Diggle, S. P. Nature Rev. Microbiol. 4, 597–607 (2006).

    Article  CAS  Google Scholar 

  3. Dubnau, D. & Losick, R. Mol. Microbiol. 61, 564–572 (2006).

    Article  CAS  Google Scholar 

  4. Veening, J. W., Smits, W. K. & Kuipers, O. P. Annu. Rev. Microbiol. 62, 193–210 (2008).

    Article  CAS  Google Scholar 

  5. Stecher, B. et al. PLoS Biol. 5, 2177–2189 (2007).

    Article  CAS  Google Scholar 

  6. Ackermann, M. et al. Nature 454, 987–990 (2008).

    Article  ADS  CAS  Google Scholar 

  7. Sturm, A. et al. PLoS Pathog. 7, e1002143 (2011).

    Article  CAS  Google Scholar 

  8. Harrison, F., Browning, L. E., Vos, M. & Buckling, A. BMC Biol. 4, 21 (2006).

    Article  Google Scholar 

  9. Rumbaugh, K. P. et al. Curr. Biol. 19, 341–345 (2009).

    Article  CAS  Google Scholar 

  10. Ellermeier, C. D., Ellermeier, J. R. & Slauch J. M. Mol. Microbiol. 57, 691–705 (2005).

    Article  CAS  Google Scholar 

  11. Baxter, M. A., Fahlen, T. F., Wilson, R. L. & Jones, B. D. Infect. Immun. 71, 1295–1305 (2003).

    Article  CAS  Google Scholar 

  12. Wickham, M. E., Brown, N. F., Boyle, E. C., Coombes, B. K. & Finlay, B. B. Curr. Biol. 17, 783–788 (2007).

    Article  CAS  Google Scholar 

  13. Raymond, B., West, S. A., Griffen, A. S. & Bonsall, M. B. Science 337, 85–88 (2012).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Brian K. Coombes.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mulder, D., Coombes, B. Cheats never prosper. Nature 494, 321–322 (2013). https://doi.org/10.1038/494321a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/494321a

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology