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Immunology

Licensed in the lungs

In multiple sclerosis, the body's own immune cells attack the brain and spinal cord. But how they get there from peripheral tissues has been a mystery. Surprisingly, the lungs might be a key transit point. See Letter p.675

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Figure 1: Autoimmune cells transit the airways.

References

  1. Odoardi, F. et al. Nature 488, 675–679 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Kojima, K. et al. J. Exp. Med. 180, 817–829 (1994).

    Article  CAS  Google Scholar 

  3. Flügel, A. et al. Immunity 14, 547–560 (2001).

    Article  Google Scholar 

  4. Bartholomäus, I. et al. Nature 462, 94–98 (2009).

    Article  ADS  Google Scholar 

  5. Denk, W., Strickler, J. H. & Webb, W. W. Science 248, 73–76 (1990).

    Article  ADS  CAS  Google Scholar 

  6. Laudanna, C. & Constantin, G. J. Immunol. Methods 273, 115–123 (2003).

    Article  CAS  Google Scholar 

  7. Johnston, B. et al. J. Immunol. 164, 3337–3344 (2000).

    Article  CAS  Google Scholar 

  8. Ransohoff, R. M. Nature 462, 41–42 (2009).

    Article  ADS  CAS  Google Scholar 

  9. Purwar, R. et al. PLoS ONE 6, e16245 (2011).

    Article  ADS  CAS  Google Scholar 

  10. Moyron-Quiroz, J. E. et al. Nature Med. 10, 927–934 (2004).

    Article  CAS  Google Scholar 

  11. Richmond, I. et al. Thorax 48, 1130–1134 (1993).

    Article  CAS  Google Scholar 

  12. van der Mei, I. A. et al. Neurol. Clin. 29, 233–255 (2011).

    Article  CAS  Google Scholar 

  13. Sibley, W. A., Bamford, C. R. & Clark, K. Lancet 1, 1313–1315 (1985).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Richard M. Ransohoff.

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Ransohoff, R. Licensed in the lungs. Nature 488, 595–596 (2012). https://doi.org/10.1038/488595a

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