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Microbiology

Slicer for DNA

Nature volume 468, pages 45–46 (2010)Cite this article

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Many bacteria and archaea protect themselves from viruses and other invasive genomes through a genetic interference pathway. The small RNAs that guide this defence specify the direct cleavage of foreign DNA. See Article p.67

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Figure 1: RNA-guided DNA cleavage by the core CRISPR machinery.

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Authors and Affiliations

  1. Erik J. Sontheimer is in the Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA. erik@northwestern.edu,

    Erik J. Sontheimer

  2. Luciano A. Marraffini is in the Laboratory of Bacteriology, Rockefeller University, New York, New York 10065, USA. marraffini@mail.rockefeller.edu,

    Luciano A. Marraffini

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  1. Erik J. Sontheimer
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  2. Luciano A. Marraffini
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Sontheimer, E., Marraffini, L. Slicer for DNA. Nature 468, 45–46 (2010). https://doi.org/10.1038/468045a

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