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Stem cells

The stress of forming blood cells

The first heartbeat is an important moment in an embryo's life. The biomechanical forces created by pulsatile flow promote the formation of haematopoietic stem cells that equip the body with its mature blood cells.

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Figure 1: Blood flow promotes development of haematopoietic stem cells (HSCs)1,2.

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Pardanaud, L., Eichmann, A. The stress of forming blood cells. Nature 459, 1068–1069 (2009). https://doi.org/10.1038/4591068a

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