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Biochemistry

Fit for an enzyme

Certain enzymes that synthesize antibiotics play a game of pass the parcel, handing biosynthetic intermediates from one active site to another. A study reveals the dynamic nature of interactions between the enzyme domains.

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Figure 1: Protein–protein interactions in megasynthase enzymes.

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Kapur, S., Khosla, C. Fit for an enzyme. Nature 454, 832–833 (2008). https://doi.org/10.1038/454832a

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