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Prostatic volume and volume-adjusted prostate-specific antigen as predictive parameters for prostate cancer patients with intermediate PSA levels

Prostate Cancer and Prostatic Diseases volume 10, pages 274–278 (2007)Cite this article

Abstract

The object of the study was to examine the usefulness of volume-adjusted prostate-specific antigen (PSA) parameters for prediction of prostate cancer in the patients with intermediate PSA levels. The subjects were 235 patients with intermediate PSA levels (range: 4.1–10.0 ng/ml) whose prostate volume (PV) and prostate transition zone volume (TZV) were evaluated between August 1996 and April 2004. PSA, PV, TZV, PSA density (PSAD) (PSA/PV) and PSA transition zone density (PSATZD) (PSA/TZV) were assessed with the receiver operating characteristic (ROC) curve and the area under the curve (AUC). Simple and multivariate logistic regression analyses were used to analyze the odds ratios of age, PSA, PSAD, PSATZD, PV, TZV, digital rectal examination (DRE) and transrectal ultrasonography (TRUS) findings. Fifty-five patients (23.4%) of 235 patients had biopsy-proven prostate cancer. The univariate analysis revealed significant differences in the mean values of age, PSAD, PSATZD, PV, TZV and DRE between the patients with cancer and the non-cancer patients. The ROC curve analysis revealed that PV, TZV, PSAD and PSATZD had significant predictive values as compared with that of PSA. However, there was no difference in AUC between them. The stepwise logistic regression analysis showed that the age, PV, PSATZD and DRE had significant predictive values, and that PSATZD had the most predictive power. In conclusion, both PSAD and PSATZD had significant predictive values in discriminating prostate cancer. Furthermore, the stepwise logistic regression analysis showed that PSATZD had the strongest predictive value.

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References

  1. Benson MC, Whang IS, Pantuck A, Ring K, Kaplan SA, Olsson CA et al. Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer. J Urol 1992; 147: 815–816.

    Article  CAS  Google Scholar 

  2. Benson MC, Whang IS, Olsson CA, McMahon DJ, Cooner WH . The use of prostate specific antigen density to enhance the predictive value of intermediate level of serum prostate specific antigen. J Urol 1992; 147: 817–821.

    Article  CAS  Google Scholar 

  3. Kalish J, Cooner WH, Graham Jr SD . Serum PSA adjusted for volume of transition zone (PSAT) is more accurate than PSA adjusted for total gland volume (PSAD) in detecting adenocarcinoma of the prostate. Urology 1994; 43: 601–606.

    Article  CAS  Google Scholar 

  4. Arai Y, Maeda H, Ishitoya S, Okubo K, Okada T, Aoki Y . Prospective evaluation of prostate specific antigen density and systematic biopsy for detecting prostate cancer in Japanese patients with normal rectal examinations and intermediate prostate specific antigen levels. J Urol 1997; 158: 861–864.

    Article  CAS  Google Scholar 

  5. Egawa S, Suyama K, Takashima R, Mizoguchi H, Kuwao S, Baba S . Prospective evaluation of prostate cancer detection by prostate-specific antigen-related parameters. Int J Urol 1999; 6: 493–501.

    Article  CAS  Google Scholar 

  6. Djavan B, Zlotta AR, Byttebier G, Shariat S, Omar M, Schulman CC et al. Prostate specific antigen density of the transition zone for early detection of prostate cancer. J Urol 1998; 160: 411–419.

    Article  CAS  Google Scholar 

  7. Kikuchi E, Nakashima J, Ishibashi M, Ohigashi T, Asakura H, Tachibana M et al. Prosate specific antigen adjusted for transition zone volume. Cancer 2000; 89: 842–849.

    Article  CAS  Google Scholar 

  8. Imai K, Ichinose Y, Kubota Y, Yamanaka H, Sato J, Saitoh M et al. Clinical significance of prostate specific antigen for early stage prostate cancer detection. Jpn J Clic Oncol 1994; 24: 160–165.

    CAS  Google Scholar 

  9. Matsuyama H, Baba Y, Yamanaka G, Yamamoto N, Naito K . Diagnostic value of prostate-specific antigen-related parameters in discriminating prostate cancer. Int J Urol 2000; 7: 409–414.

    Article  CAS  Google Scholar 

  10. Maeda H, Arai Y, Aoki Y, Okubo K, Okada T, Maekawa S . Complex prostate-specific antigen and its volume indexes in the detection of prostate cancer. Urology 1999; 54: 225–228.

    Article  CAS  Google Scholar 

  11. Kang SH, Bae JH, Park HS, Yoon DK, Moon DG, Kim JJ et al. Prostate-specific antigen adjusted for the transition zone volume as a second screening test: a prospective study of 248 cases. Int J Urol 2006; 13: 910–914.

    Article  Google Scholar 

  12. Hanley JA, McNeil BJ . The meaning and use of the area under a receiver operating characteristics (ROC) curve. Radiology 1982; 143: 29–36.

    Article  CAS  Google Scholar 

  13. Hanley JA, McNeil BJ . A method of comparing the area under receiver operating characteristic curve derived from the same cases. Radiology 1983; 148: 839–843.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Nara Medical University, Nara, Japan

    N Tanaka, K Fujimoto, Y Chihara, M Torimoto & Y Hirao

  2. Department of Pathology, Nara Medical University, Nara, Japan

    N Konishi

  3. Department of Public Health, Social Medicine and Medical Information, Graduate School of Medicine, Ehime University, Ehime, Japan

    I Saito

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  1. N Tanaka
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  2. K Fujimoto
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  3. Y Chihara
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  4. M Torimoto
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  6. N Konishi
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Correspondence to N Tanaka.

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Tanaka, N., Fujimoto, K., Chihara, Y. et al. Prostatic volume and volume-adjusted prostate-specific antigen as predictive parameters for prostate cancer patients with intermediate PSA levels. Prostate Cancer Prostatic Dis 10, 274–278 (2007). https://doi.org/10.1038/sj.pcan.4500957

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  • DOI: https://doi.org/10.1038/sj.pcan.4500957

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