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Evaluating the use of early hormonal therapy in patients with localised or locally advanced prostate cancer

Prostate Cancer and Prostatic Diseases volume 8, pages 140–151 (2005)Cite this article

Abstract

This article evaluates the use of early hormonal therapy in patients with localised or locally advanced prostate cancer. In patients receiving radiotherapy, an overall survival benefit is proven for adjuvant goserelin (‘Zoladex’) in locally advanced disease. Adjuvant to radical prostatectomy, castration (goserelin or orchiectomy) has demonstrated an overall survival benefit in patients with lymph node metastases. Survival advantages have not yet been proven with nonsteroidal antiandrogens, but immediate or adjuvant bicalutamide (‘Casodex’) improves objective progression-free survival in patients with locally advanced disease, with certain quality-of-life advantages over castration.

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Acknowledgements

Editorial support was provided by Cath Carsberg, PhD and financial assistance for this support was provided by AstraZeneca.

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  1. Department of Urology, Royal Free Hospital, London, UK

    A V Kaisary

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Correspondence to A V Kaisary.

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‘Casodex’ and ‘Zoladex’ are trademarks of the AstraZeneca group of companies.

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Kaisary, A. Evaluating the use of early hormonal therapy in patients with localised or locally advanced prostate cancer. Prostate Cancer Prostatic Dis 8, 140–151 (2005). https://doi.org/10.1038/sj.pcan.4500800

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