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Stromal–epithelial measurements of prostate cancer in native Japanese and Japanese-American men

Prostate Cancer and Prostatic Diseases volume 7, pages 232–237 (2004)Cite this article

Abstract

We measured the histologic stromal and epithelial tissue components of the benign (normal) and malignant tissue compartments of Japanese-Americans (J-A) and native Japanese (NJ) men living in Japan. The patient cohort included 25 NJ men undergoing radical prostatectomy (RP) in Nagoya, Japan and 25 J-A (second or third generation US born). We conducted tissue image quantitation (in-house image software) of the stromal and epithelial compartments in malignant and adjacent normal tissue areas from a tissue microarray (TMA) selected from radical prostatectomy (RP) blocks. Stromal–epithelial (S–E) areas were determined using immunohistochemical stains for CAM-5.2 epithelial cytokeratin marker and the Masson trichrome stain to measure the stroma component. We observed differences in the volumes of normal and cancer epithelium and stroma within both the J-A and NJ study populations (P<0.01). Only the individual average cancer epithelium (CE) volume (JA=24.1 vs NJ=29.9) differed significantly between the NJ and J-A study populations (P=0.03). Consequently, the S–E ratio in NJ group was significantly different from that of J-A population (P=0.05). The decrease in S–E ratio noted in the malignant tissues of NJ prostate tissue may provide a biological marker for differentiation of the two groups and suggests a need for further investigations into the molecular basis for these histologic differences.

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Acknowledgements

This work was supported by NIH/NCI SPORE Grant P50CA58236; NIH/NCI Early Detection Research Network Grant #CA8623-02; Prostate Cancer Foundation (CaPCURE); The Elsa Pardee Foundation. This study was also supported by a generous gift from the Urological Sciences Research Foundation (Culver City, CA, USA). The tissue microarrays were produced by Helen Fedor through the Pathology Core (P.I. Angelo De Marzo) of the Johns Hopkins University Prostate Cancer SPORE Grant.

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Authors and Affiliations

  1. Johns Hopkins University School of Medicine, Baltimore, MD, USA

    R W Veltri, J Park, C van Rootselaar, M A Khan & A W Partin

  2. Immunicon Inc., Quakertown, PA, USA

    M C Miller

  3. UCLA, Los Angeles, and Urological Sciences Research Foundation, Culver City, CA, USA

    L Marks

  4. Kyoto Prefectural University of Medicine and Nagoya Urology Hospital, Kyoto, Japan

    M Kojima

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  1. R W Veltri
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  2. J Park
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  3. M C Miller
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  4. L Marks
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  6. C van Rootselaar
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  7. M A Khan
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  8. A W Partin
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Correspondence to R W Veltri.

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Veltri, R., Park, J., Miller, M. et al. Stromal–epithelial measurements of prostate cancer in native Japanese and Japanese-American men. Prostate Cancer Prostatic Dis 7, 232–237 (2004). https://doi.org/10.1038/sj.pcan.4500738

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