Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Paper
  • Published:

Prostate cancer detection and tumor characteristics in men with multiple biopsy sessions

Prostate Cancer and Prostatic Diseases volume 7, pages 238–242 (2004)Cite this article

Abstract

Purposes: To address prostate cancer (PCa) detection with respect to the number of biopsy sessions performed, to identify risk factors for detection after a negative biopsy, and to analyze the clinical characteristics of the detected tumors.

Scope: Only biopsied men (sextant) were included. A total of 1011 biopsy sessions were carried out in 770 men; 172 underwent a second prostate biopsy and 51 a third biopsy. During the first biopsy round, 111 cancers were found (14.4%), 27 in the second (15.7%), and five during the third round (9.8%), P=0.156. Only high-grade PIN or atypia were identified as independent predictors or PCa detection in subsequent biopsies (P=0.008). A nonsignificant increase of clinically localized tumors, and a decrease of metastatic and poorly differentiated cases were found when more biopsy sessions were needed for detection.

Conclusions: A nonsignificant trend to lower cancer detection rates and less clinical relevance of the tumors detected can be observed when more biopsy rounds are needed for detection.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. De Koning HJ et al. Large-scale randomized prostate cancer screening trials: program performances in the European Randomized Screening for Prostate Cancer trial and the Prostate, Lung, Colorectal and Ovary cancer trial. Int J Cancer 2002; 97: 237–244.

    Article  CAS  Google Scholar 

  2. Chang JJ, Shinohara K, Bhargava V, Presti JC . Prospective evaluation of lateral biopsies of the peripheral zone for prostate cancer detection. J Urol 1998; 160: 2111–2114.

    Article  CAS  Google Scholar 

  3. Presti JC, Chang JJ, Bhargava V, Shinohara K . The optimal systematic prostate biopsy scheme should include 8 rather than 6 biopsies: results of a prospective clinical trial. J Urol 2000; 163: 163–167.

    Article  Google Scholar 

  4. Bauer JJ et al. Three-dimensional computer-simulated prostate models: lateral prostate biopsies increase the detection rate of prostate cancer. Urology 1999; 53: 961–967.

    Article  CAS  Google Scholar 

  5. Zlotta AR, Raviv G, Schulman CC . Clinical prognostic criteria for later diagnosis of prostate carcinoma in patients with initial isolated prostatic intraepithelial neoplasia. Eur Urol 1996; 30: 249–255.

    Article  CAS  Google Scholar 

  6. Borboroglu PG, Sur RL, Roberts JL, Amling CL . Repeat biopsy strategy in patients with atypical small acinar proliferation or high grade prostatic intraepithelial neoplasia on initial prostate needle biopsy. J Urol 2001; 166: 866–870.

    Article  CAS  Google Scholar 

  7. Djavan B, Remzi M, Marberger M . When to biopsy and when to stop biopsying. Urol Clin N Am 2003; 30: 253–262.

    Article  Google Scholar 

  8. Djavan B et al. Optimal predictors of prostate cancer on repeat biopsy: a prospective study of 1051 men. J Urol 2000; 163: 1144–1149.

    Article  CAS  Google Scholar 

  9. Remzi M et al. An artificial neural network to predict the outcome of repeat prostate biopsies. Urology 2003; 62: 456–460.

    Article  Google Scholar 

  10. Lopez-Corona E et al. A nomogram for predicting a positive repeat prostate biopsy in patients with a previous negative biopsy session. J Urol 2003; 170: 1184–1188.

    Article  Google Scholar 

  11. Mian BM et al. Predictors of cancer in repeat extended multisite prostate biopsy in men with previous negative extended multisite biopsy. Urology 2002; 60: 836–840.

    Article  Google Scholar 

  12. Djavan B et al. Prospective evaluation of prostate cancer detected on biopsies 1, 2, 3 and 4: when should we stop? J Urol 2001; 166: 1679–1683.

    Article  CAS  Google Scholar 

  13. Ciatto S, Vis AN, Finne P . How to improve the specificity and sensitivity of biopsy technique in screening. BJU Int 2003; 92 (Suppl 2): 79–83.

    Article  Google Scholar 

  14. Vis AN et al. The predictive value for prostate cancer of lesions that raise suspicion of concomitant carcinoma: an evaluation from a randomized, population-based study of screening for prostate cancer. Cancer 2001; 92: 524–534.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Supported in part by the grants from Spanish Fondo de Investigación Sanitaria and members of the European Randomized Study of Screening for Prostate Cancer (ERPSC).

Author information

Authors and Affiliations

  1. Urology Department, Hospital Universitario de Getafe, Madrid, Spain

    M Lujan, I Fernandez & A Berenguer

  2. Urology Department, Hospital de Fuenlabrada, Madrid, Spain

    A Paez

  3. Pathology Department, Hospital Universitario de Getafe, Madrid, Spain

    C Santonja

  4. Biochemistry Department, Hospital Universitario de Getafe, Madrid, Spain

    T Pascual

Authors
  1. M Lujan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Paez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C Santonja
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T Pascual
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I Fernandez
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A Berenguer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A Berenguer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lujan, M., Paez, A., Santonja, C. et al. Prostate cancer detection and tumor characteristics in men with multiple biopsy sessions. Prostate Cancer Prostatic Dis 7, 238–242 (2004). https://doi.org/10.1038/sj.pcan.4500730

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.pcan.4500730

Keywords

This article is cited by

Search

Advanced search

Quick links