Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Paper
  • Published:

Impact of biochemical failure on long-term clinical outcome after radical prostatectomy for prostate cancer in Japan

Prostate Cancer and Prostatic Diseases volume 7, pages 152–157 (2004)Cite this article

Abstract

Detailed information is needed to understand the impact of biochemical failure (bF) on long-term outcome after definitive therapy for prostate cancer. In all, 223 consecutive men treated with radical retropubic prostatectomy were followed and long-term clinical outcome was investigated. Pathological examination revealed more locally advanced tumors in this study compared with the typical cohorts seen in the Western series. The Cox proportional hazards model indicates pretreatment prostate-specific antigen levels and risk group stratification to be a significant predictors for bF (P<0.05), but not for overall survival. Seminal vesicle involvement was a significant predictor of systemic progression, cancer death and overall survival (P<0.05). Positive surgical margin and bF were also found to be independent predictors of overall survival (P<0.05). In contrast to reports from Western countries, this study found a significant correlation between bF after radical prostatectomy and overall survival. This may reflect years-later detection of prostate cancer in Japan compared with Western series. Biochemical failure may ultimately be translated into decreased overall survival after sufficient follow-up.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Pound CR et al. Natural history of progression after PSA elevation following radical prostatectomy. JAMA 1999; 281: 1591–1597.

    Article  CAS  Google Scholar 

  2. Jhaveri FM, Zippe CD, Klein EA, Kupelian PA . Biochemical failure does not predict overall survival after radical prostatectomy for localized prostate cancer: 10-year results. Urology 1999; 54: 884–890.

    Article  CAS  Google Scholar 

  3. Kupelian PA et al. Impact of biochemical failure on overall survival after radiation therapy for localized prostate cancer in the PSA era. Int J Radial Oncol Biol Phys 2002; 52: 704–711.

    Article  CAS  Google Scholar 

  4. D'Amico AV et al. Pretreatment predictors of time to cancer specific death after prostate specific antigen failure. J Urol 2003; 169: 1320–1324.

    Article  Google Scholar 

  5. Machida T et al. Clinical evaluation of a new kit (IMx PA Dainapack) for detection of serum prostate specific antigen. Acta Urol Japon 1993; 39: 977–984.

    CAS  Google Scholar 

  6. International Union against Cancer. TNM Atlas, 3rd edn., 2nd revision. Springer: New York 1992; pp 241–250.

  7. UICC International Union. In: Sobin LH, Wittekind CH (eds). UICC International Union Against Cancer, TNM classification of malignant tumors. 6th edn. John Wiley & Sons, Inc: New York 2002; pp 184–187.

  8. Egawa S et al. Infrequent involvement of the anterior base in low-risk patients with clinically localized prostate cancer and its possible significance in definitive radiation therapy. Jpn J Clin Oncol 2000; 30: 126–130.

    Article  CAS  Google Scholar 

  9. Japanese Urological Association. General Rule for Clinical and Pathological Studies on Prostatic Cancer, 3rd edn. Japan: The Japanese Pathological Society 2001.

  10. National Institute of Population and Social Security Research: Population Projections for Japan: 2001–2050 (with long-range population projects: 2051–2100).

  11. Egawa S . Detection of prostate cancer by prostate-specific antigen. Biomed Pharmacother 2001; 55: 130–134.

    Article  CAS  Google Scholar 

  12. Egawa S et al. Impact of life expectancy and tumor doubling time on the clinical significance of prostate cancer in Japan. Jpn J Clin Oncol 1997; 27: 394–400.

    Article  CAS  Google Scholar 

  13. Partin AW, Oesterling JE . The clinical usefulness of prostate specific antigen: update 1994. J Urol 1994; 15: 1358–1368.

    Article  Google Scholar 

  14. Zincke H et al. Long-term (15 years) results after radical prostatectomy for clinically localized (stage T2c or lower) prostate cancer. J Urol 1994; 152: 1850–1857.

    Article  CAS  Google Scholar 

  15. Catalona WJ, Smith DS . Cancer recurrence and survival rates after anatomic radical retropubic prostatectomy for prostate cancer: intermediate-term results. J Urol 1998; 160: 2428–2434.

    Article  CAS  Google Scholar 

  16. Gerber GS et al. Results of radical prostatectomy in men with clinically localized prostate cancer. JAMA 1996; 276: 615–619.

    Article  CAS  Google Scholar 

  17. Hull GW et al. Cancer control with radical prostatectomy alone in 1000 consecutive patients. J Urol 2002; 167: 528–534.

    Article  Google Scholar 

  18. Egawa S et al. Observations of prostate specific antigen doubling time in Japanese patients with nonmetastatic prostate carcinoma. Cancer 1999; 86: 463–469.

    Article  CAS  Google Scholar 

  19. Bianco Jr FJ et al. Radical prostatectomy nomograms in black American men: accuracy and applicability. J Urol 2003; 170: 73–77.

    Article  Google Scholar 

Download references

Acknowledgements

We thank WA Thomasson, PhD, for expert editorial assistance.

Author information

Authors and Affiliations

  1. Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

    S Egawa, K Matsumoto, K Suyama & S Baba

  2. Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

    S Kuwao

  3. Department of Urology, Kurashiki Central Hospital, Kurashiki, Okayama, Japan

    Y Matsui & Y Arai

Authors
  1. S Egawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y Matsui
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K Suyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Y Arai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S Kuwao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S Baba
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S Egawa.

Additional information

Supported in part by a grant from the Ministry of Health and Welfare of Japan (11-10) and the Foundation for Promotion of Cancer Research in Japan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Egawa, S., Matsui, Y., Matsumoto, K. et al. Impact of biochemical failure on long-term clinical outcome after radical prostatectomy for prostate cancer in Japan. Prostate Cancer Prostatic Dis 7, 152–157 (2004). https://doi.org/10.1038/sj.pcan.4500715

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.pcan.4500715

Keywords

This article is cited by

Search

Advanced search

Quick links