Abstract
Pathologic characteristics of the prostatic adenocarcinoma in Koreans are not clear. We studied 132 cases of prostatectomy specimens using mapping analysis to discover the pathologic characteristics of the Korean prostatic adenocarcinoma. Mean values were as follows: serum prostate-specific antigen level (sPSA), 16.4 ng/ml; tumor volume, 27.5%; size, 2.4 cm; Gleason score, 7.7; and p53 expression, 9.8%. Rates of multifocal tumors and high-grade prostatic intraepithelial neoplasm (HPIN) were 33.3 and 65.2%. The Gleason score, tumor volume%, tumor size and sPSA were correlated with each other. Korean prostatic adenocarcinomas showed higher Gleason scores, lower rates of HPIN and multifocality, and lower p53 expression in comparison to Western prostatic adenocarcinomas. These data may be a basis for pathologic characteristics of Korean prostatic adenocarcinoma that has now been increasing.
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References
Catalona WJ, Scott WW . Carcinoma of the prostate: a review. J Urol 1978; 119: 1–8.
Landis SH, Murray T, Bolden S, Wergo PA . Cancer statistics, 1998. CA J Clin 1998; 48: 6–29.
Elder JS, Catalona WJ . Management of newly diagnosed metastatic carcinoma of the prostate. Urol Clin North Am 1984; 11: 283–295.
Gleason DF, Mellinger GT . Veterans Administration Cooperative Urological Research Group. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol 1974; 111: 58–64.
Rosai J . Male reproductive system. In: Ackerman's Surgical Pathology, 8th edn. Mosby, St Louis, 1996, pp 1221–1256.
Bostwick DG . Neoplasms of the prostate. In: Bostwick DG, Eble JN (eds). Urologic Surgical Pathology. Mosby, St. Louis, 1997, pp 343–422.
Chia S-J et al. Prostate tumours from an Asian population: examination of bax, bcl-2, p53 and ras and identification of bax as a prognostic marker. Br J Cancer 2000; 83: 761–768.
Cancer Registration and Biostatics Branch, National Cancer Center. Cancer Statistics in Korea, 2002.
Uchida T et al. Infrequent involvement of p53 gene mutations in the tumorigenesis of Japanese prostate cancer. Br J Cancer 1993; 68: 751–755.
Watanabe M et al. p53 gene mutations in human prostate cancers in Japan: different mutation spectra between Japan and Western countries. Jpn J Cancer Res 1994; 85: 904–910.
Anwar K et al. Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas. Cancer Res 1992; 52: 5991–5996.
Shiraishi T et al. Mutations of ras gene are relatively frequent in Japanese prostate cancers: pointing to genetic differences between populations. Anticancer Res 1998; 18: 2789–2792.
Bostwick DG, Brawer MK . Prostatic intraepithelial neoplasia and early invasion in prostate cancer. Cancer 1987; 59: 788–794.
Amin MB, Ro JY, Ayala AG . Putative precursor lesion of prostatic adenocarcinoma: fact of fiction? Mod Pathol 1993; 6: 476–483.
Bostwick DG . High-grade prostatic intraepithelial neoplasia: the most likely precursor of the prostate cancer. Cancer 1995; 75: 1823–1836.
Byar DP, Mostofi FK . Carcinoma of the prostate: prognostic evaluation of certain pathologic features in 208 radical prostatectomys. Cancer 1972; 30: 5–13.
Villers A, McNeal JE, Frelha FS, Stamey TA . Multiple cancers in the prostate. Cancer 1992; 70: 2313–2318.
Haggman M et al. Characteristics of localized prostate cancer: distribution, grading and pT-staging in radical prostatectomy specimens. Scand J Urol Nephrol 1993; 27: 7–13.
Lee TJ, Choe MS, Kim CS, Ro JY . Clinicopathologic features of prostatic adenocarcinoma: a study of 58 radical prostatectomy specimens. Korean J Pathol 1999; 33: 1067–1075.
Oh W, Song SY, Choi HY . Comparison of clinical and pathological findings in unifocal and multifocal prostate cancer. Korean J Urol 1999; 40: 1289–1294.
Hong JH et al. Prostatic intraepithelial neoplasia in radical prostatectomy specimens as a prognostic factor. Korean J Urol 2000; 41: 147–151.
Choi YL, Kim SR, Song SY, Choi HY . Pathologic characteristics of Korean prostatic adenocarcinoma: a mapping analysis of 60 cases. Korean J Pathol 2001; 35: 35–40.
Qian J, Wollan P, Bostwick DG, The extent and multicentricity of high-grade prostatic intraepithelial neoplasia in clinically localized prostatic adenocarcinoma. Hum Pathol 1997; 28: 143–148.
Rob K et al. Predictability and significance of multifocal prostate cancer in the radical prostatectomy specimen. Eur Urol 1998; 33 (Suppl): 70.
Bookstein R, MacGrogan D, Hilsenbeck SG, Sharkey F, Allred DC . p53 is mutated in a subset of advanced-stage prostate cancers. Cancer Res 1993; 53: 3369–3373.
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Song, S., Kim, S., Ahn, G. et al. Pathologic characteristics of prostatic adenocarcinomas: a mapping analysis of Korean patients. Prostate Cancer Prostatic Dis 6, 143–147 (2003). https://doi.org/10.1038/sj.pcan.4500636
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DOI: https://doi.org/10.1038/sj.pcan.4500636
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