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Investigating the clinical utility of the percent of positive prostate biopsies in predicting PSA outcome following local therapy for patients with clinically localized prostate cancer

Prostate Cancer and Prostatic Diseases volume 3, pages 259–264 (2000)Cite this article

Abstract

The clinical utility of the percent of positive prostate biopsies in predicting prostate-specific antigen (PSA) outcome following radical prostatectomy (RP), or external beam radiation therapy (RT), for men with PSA detected, or clinically palpable prostate cancer was investigated.

After accounting for the established prognostic significance of the PSA level, biopsy Gleason score and the clinical T-stage, the percent of positive prostate biopsies added clinically significant information regarding time to PSA failure following RP. These findings were validated in the intermediate risk patients using an independent surgical and radiation data set.

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Authors and Affiliations

  1. Joint Center for Radiation Therapy, Harvard Medical School, Hospital of the University of Pennsylvania,

    AV D'Amico, B Silver, L Henry, M Hurwitz, I Kaplan & CJ Beard

  2. Department of Radiation Oncology, Hospital of the University of Pennsylvania,

    R Whittington

  3. Department of Urology, Hospital of the University of Pennsylvania,

    SB Malkowicz & A Wein

  4. Department of Mathematics, University of Millersville,

    D Schultz

  5. Department of Pathology, Hospital of the University of Pennsylvania,

    JE Tomaszewski

  6. Department of Pathology, Brigham and Women's Hospital,

    AA Renshaw

  7. Department of Urology, Brigham and Women's Hospital,

    JP Richie

Authors
  1. AV D'Amico
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  2. R Whittington
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  3. SB Malkowicz
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  4. D Schultz
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  5. B Silver
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  6. L Henry
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  7. M Hurwitz
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  8. I Kaplan
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  9. CJ Beard
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  10. JE Tomaszewski
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  11. AA Renshaw
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  12. A Wein
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  13. JP Richie
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Corresponding author

Correspondence to AV D'Amico.

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Cite this article

D'Amico, A., Whittington, R., Malkowicz, S. et al. Investigating the clinical utility of the percent of positive prostate biopsies in predicting PSA outcome following local therapy for patients with clinically localized prostate cancer. Prostate Cancer Prostatic Dis 3, 259–264 (2000). https://doi.org/10.1038/sj.pcan.4500413

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  • DOI: https://doi.org/10.1038/sj.pcan.4500413

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