Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Paper
  • Published:

Immunohistochemical BCL-2 and Ki-67 expression predict survival in prostate cancer patients followed expectantly

Prostate Cancer and Prostatic Diseases volume 1, pages 268–275 (1998)Cite this article

An Erratum to this article was published on 21 May 1999

Abstract

The prognostic value of BCL-2 expression, solely and combined with Ki-67 expression, was determined in prostate cancer patients followed expectantly. Furthermore, associations with well established prognostic markers were tested. Formalin fixed, paraffin-embedded tumour tissue obtained at diagnosis was immunohistochemically investigated in 221 patients with a 15 y median follow-up time. BCL-2 protein was expressed in 114 (52%) tumours and was significantly associated with tumour stage (P=0.01). The prognostic value of BCL-2 expression was significant, using both disease-specific (P=0.0015) and overall survival (P=0.005) as endpoint. Patients with a combined BCL-2 negative/Ki-67 ‘low’ tumour had the most favourable prognosis. This combined BCL-2/Ki-67 variable was of independently prognostic value in both the entire population (P=0.0001) and in the clinically localized subpopulation (P=0.035).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Experimental Clinical Oncology, The Danish Cancer Society, Denmark

    M Borre, B Stausbøl-Grøn & J Overgaard

  2. The Department of Urology, Aarhus University Hospital, Denmark

    M Borre & B Nerstrøm

Authors
  1. M Borre
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B Stausbøl-Grøn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B Nerstrøm
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Overgaard
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Borre, M., Stausbøl-Grøn, B., Nerstrøm, B. et al. Immunohistochemical BCL-2 and Ki-67 expression predict survival in prostate cancer patients followed expectantly. Prostate Cancer Prostatic Dis 1, 268–275 (1998). https://doi.org/10.1038/sj.pcan.4500252

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.pcan.4500252

Keywords

This article is cited by

Search

Advanced search

Quick links