Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neuroscience

Obsessed with grooming

Roughly 2% of humans suffer from obsessive compulsive disorder, but a lack of animal models has impeded research into this condition. Could a genetically engineered mouse model provide an exciting lead?

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Chamberlain, S. R., Menzies, L., Sahakian, B. J. & Fineberg, N. A. Am. J. Psychiatry 164, 568–574 (2007).

    Article  Google Scholar 

  2. Welch, J. M. et al. Nature 448, 894–900 (2007).

    Article  ADS  CAS  Google Scholar 

  3. Hollander, E., Kim, S., Khanna, S. & Pallanti, S. CNS Spectr. 12 (suppl. 3), 5–13 (2007).

    Article  Google Scholar 

  4. Merikangas, K. R. & Risch, N. Am. J. Psychiatry 160, 625–635 (2003).

    Article  Google Scholar 

  5. Robinson, D. et al. Arch. Gen. Psychiatry 52, 393–398 (1995).

    Article  CAS  Google Scholar 

  6. Pujol, J. et al. Arch. Gen. Psychiatry 61, 720–730 (2004).

    Article  Google Scholar 

  7. Bloch, M. H., Leckman, J. F., Zhu, H. & Peterson, B. S. Neurology 65, 1253–1258 (2005).

    Article  Google Scholar 

  8. Remijnse, P. L. et al. Arch. Gen. Psychiatry 63, 1225–1236 (2006).

    Article  Google Scholar 

  9. Bice, P. J. et al. Behav. Genet. 36, 248–260 (2006).

    Article  Google Scholar 

  10. Shahbazian, M. et al. Neuron 35, 243–254 (2002).

    Article  CAS  Google Scholar 

  11. Clapcote, S. J. et al. Neuron 54, 387–402 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hyman, S. Obsessed with grooming. Nature 448, 871–872 (2007). https://doi.org/10.1038/448871a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/448871a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing