Inhibition of the insulin-signalling pathway leads to insulin resistance, an early step in the development of type 2 diabetes. A novel family of protein activators seems to act near the pathway's inception.
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Jackson, C. Kicking off the insulin cascade. Nature 444, 833–834 (2006). https://doi.org/10.1038/444833a
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DOI: https://doi.org/10.1038/444833a
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