HIV-1 prompts a massive cellular immune response, but eventually it tires the immune cells. Blocking the activation of a cell receptor called PD-1 might restore these exhausted cells.
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Rowland-Jones, S., Dong, T. Tired T cells turn around. Nature 443, 282–283 (2006). https://doi.org/10.1038/443282a
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DOI: https://doi.org/10.1038/443282a