Abstract
We do not consider that our inferences about FLASH function are misleading because they were deduced from functional analyses1. We originally identified the death-effector domain (DED)-binding activity of the DED-recruiting domain (DRD) of FLASH before analysing the structural homology between the DED and DRD domains. Moreover, we deduced the self-association activity of FLASH through its central region from functional analysis of several deletion mutants of mouse FLASH. We note that self-association activity of CED-4-homologous proteins is required for the activation of caspases2.
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Kimura, T., Imai, Y. & Yonehara, S. Searching for FLASH domains. Nature 401, 662–663 (1999). https://doi.org/10.1038/44320
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DOI: https://doi.org/10.1038/44320
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