HIV-1 replicates itself by integrating into its host cell's DNA. Studies in cell culture reveal that nuclear-membrane proteins aid engagement of the viral DNA with that of its host before integration.
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References
Jacque, J. -M. & Stevenson, M. Nature 441, 641–645 (2006).
Turlure, F., Devroe, E., Silver, P. A. & Engelman, A. Front. Biosci. 9, 3187–3208 (2004).
Gruenbaum, Y., Margalit, A., Goldman, R. D., Shumaker, D. K. & Wilson, K. L. Nature Rev. Mol. Cell Biol. 6, 21–31 (2005).
Lee, M. S. & Craigie, R. Proc. Natl Acad. Sci. USA 95, 1528–1533 (1998).
Segura-Totten, M. & Wilson, K. L. Trends Cell Biol. 14, 261–266 (2004).
Furukawa, K. et al. J. Cell Sci. 116, 3811–3823 (2003).
Margali, A., Segura-Totten, M., Gruenbaum, Y. & Wilson, K. L. Proc. Natl Acad. Sci. USA 102, 3290–3295 (2005).
Suzuki, Y., Yang, H. & Craigie, R. EMBO J. 23, 4670–4678 (2004).
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Li, M., Craigie, R. HIV goes nuclear. Nature 441, 581–582 (2006). https://doi.org/10.1038/441581a
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DOI: https://doi.org/10.1038/441581a
