To correctly ‘play’ the DNA score in our genome, cells must read another notation that overlays it — the epigenetic code. A global effort to decode it is now in the making, reports Jane Qiu.
Access options
Subscribe to Journal
Get full journal access for 1 year
220,50 €
only 4,32 € per issue
All prices include VAT for France.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.
References
- 1.
Fraga, M. F. et al. Proc. Natl Acad. Sci. USA 102, 10604–10609 (2005).
- 2.
Waddington, C. Endeavour 1, 18–20 (1942).
- 3.
Waterland, R. A. & Jirtle, R. L. Mol. Cell. Biol. 23, 5293–5300 (2003).
- 4.
Weaver, I. C. G. et al. J. Neurosci. 25, 11045–11054 (2005).
- 5.
Lieb, J. D. et al. Cytogenet. Genome Res. 114, doi:10.1159/000091922 (2006).
- 6.
Rakyan, V. K. et al. PLoS Biol. 2, e405 (2004).
- 7.
Feinberg, A. P. & Jones, P. A. Workshop on Defining the Epigenome http://dcb. nci.nih.gov/Workshoprpt.cfm (2006).
- 8.
Rauscher, F. J. III Cancer Res. 65, 11229 (2005).
- 9.
Jones, P. A. & Martienssen, R. Cancer Res. 65, 11241–11246 (2005).
Author information
Affiliations
Jane Qiu is an editor at Nature Reviews Neuroscience.
- Jane Qiu
Authors
Search for Jane Qiu in:
Rights and permissions
To obtain permission to re-use content from this article visit RightsLink.
About this article
Further reading
-
1.
Metabole programmering: het belang van ‘de eerste 1000 dagen’ voor de latere gezondheid van het kind
JGZ Tijdschrift voor jeugdgezondheidszorg (2016)
-
2.
Epigenetik bei entzündlichen Systemerkrankungen
Der Internist (2014)
-
3.
DREAMing of a patent-free human genome for clinical sequencing
Nature Biotechnology (2013)
-
4.
Mutations in epigenetic regulators in myelodysplastic syndromes
International Journal of Hematology (2012)
-
5.
Transgenerational neuroendocrine disruption of reproduction
Nature Reviews Endocrinology (2011)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.