Abstract
Nitric oxide (NO) has anti-apoptotic actions in hepatocytes in vitro and in vivo. The protection is mediated via the S-nitrosylation of procaspases as well as the active caspase enzymes. NO stimulation of the cGMP/protein kinase G pathway also appears to contribute to the protective effect of NO. Here we review the evidence for the direct inhibition of NO with the apoptotic signaling pathways in hepatocytes.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Corresponding author
Additional information
Edited by P Nicotera
Rights and permissions
About this article
Cite this article
Li, J., Billiar, T. The anti-apoptotic actions of nitric oxide in hepatocytes. Cell Death Differ 6, 952–955 (1999). https://doi.org/10.1038/sj.cdd.4400579
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.cdd.4400579
Keywords
This article is cited by
-
First trimester placental endothelial cells from pregnancies with abnormal uterine artery Doppler are more sensitive to apoptotic stimuli
Laboratory Investigation (2019)
-
Inhibition of suicidal erythrocyte death by nitric oxide
Pflügers Archiv - European Journal of Physiology (2008)
-
Regulation of the apoptosis–necrosis switch
Oncogene (2004)
-
Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis
Cell Death & Differentiation (2003)