The next large-scale human genome project after HapMap should catalogue inherited variation in the general population that directly affects gene function, argues Richard Gibbs.
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References
International HapMap Consortium Nature 437, 1299–1320 (2005).
Gibbs, R. A. et al. Genomics 7, 235–244 (1990).
Institute of Medical Genetics, Cardiff, UK http://www.hgmd.cf.ac.uk/hgmd0.html
Belmont, J. W. & Gibbs, R. A. Am. J. Pharmacogenom. 4, 253–262 (2004).
Pritchard, J. K. & Cox, N. J. Hum. Mol. Genet. 11, 2417–2423 (2004).
Reich, D. E. & Lander, E. S. Trends Genet. 17, 502–510 (2001).
Cohen, J. et al. Nature Genet. 37, 161–165 (2005).
http://www.sanger.ac.uk/genetics/exon/ and http://www.celera.com/celera/applera_genomics
Botstein, D. & Risch, N. Nature Genet. 33 (suppl.), 228–237 (2003).
Working Group on Biomedical Technology http://www.genome.gov/Pages/About/NACHGR/May2005NACHGRAgenda/ReportoftheWorkingGrouponBiomedicalTechnology.pdf
Lin, Z., Owen, A. B. & Altman, R. B. Science 305, 183 (2004).
Acknowledgements
Thanks to J. Belmont, D. Nelson and F. Yu for discussions and for reading the manuscript.
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Gibbs, R. Deeper into the genome. Nature 437, 1233–1234 (2005). https://doi.org/10.1038/4371233a
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DOI: https://doi.org/10.1038/4371233a
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