Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neurobiology

Ballads of a protein quartet

The fate of neurons in the developing brain and in Alzheimer's disease may lie with a four-protein complex that regulates the cleavage of two molecules spanning the cell membrane. The role of each protein is now being unveiled.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The γ-secretase protein quartet, and its roles in brain development and Alzheimer's disease.

References

  1. Haass, C. & De Strooper, B. Science 286, 916–919 (1999).

    Article  CAS  Google Scholar 

  2. Selkoe, D. J. Curr. Opin. Neurobiol. 10, 50–57 (2000).

    Article  CAS  Google Scholar 

  3. Takasugi, N. et al. Nature 422, 438–441 (2003).

    Article  CAS  ADS  Google Scholar 

  4. Leissring, M. A. et al. Proc. Natl Acad. Sci. USA 99, 4697–4702 (2002).

    Article  CAS  ADS  Google Scholar 

  5. Yu, G. et al. Nature 407, 48–54 (2000).

    Article  CAS  ADS  Google Scholar 

  6. Francis, R. et al. Dev. Cell 3, 85–97 (2002).

    Article  CAS  Google Scholar 

  7. Beher, D. & Shearman, M. S. Biochem. Soc. Trans. 30, 534–537 (2002).

    Article  CAS  Google Scholar 

  8. Edbauer, D. et al. Nature Cell Biol. (in the press).

  9. Baron, M. et al. Mol. Membr. Biol. 19, 27–38 (2002).

    Article  CAS  Google Scholar 

  10. Panegyres, P. K. Rev. Neurosci. 12, 1–39 (2001).

    Article  CAS  Google Scholar 

  11. Chan, S. L. et al. Neuromol. Med. 2, 167–196 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mark P. Mattson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mattson, M. Ballads of a protein quartet. Nature 422, 385–387 (2003). https://doi.org/10.1038/422385a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/422385a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing