Activation of the nuclear factor NF-κB has been linked with many human cancers. But in tumours of some tissues this molecule is inactive. New work examines how turning off NF-κB promotes cancer in one tissue, the skin.
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References
Sen, R. & Baltimore, D. Cell 47, 921–928 (1986).
Karin, M., Cao, Y., Greten, F. R. & Li, Z. W. Nature Rev. Cancer 2, 301–310 (2002).
Mayo, M. W. et al. Science 278, 1812–1815 (2002).
Seitz, C. S., Lin, Q., Deng, H. & Khavari, P. A. Proc. Natl Acad. Sci. USA 95, 2307–2312 (1998).
van Hogerlinden, M., Rozell, B. L., Ahrlund-Richter, L. & Toftgard, R. Cancer Res. 59, 3299–3303 (1999).
Dajee, M. et al. Nature 421, 639–643 (2003).
Ghosh, S. & Karin, M. Cell 109, S81–S96 (2002).
Deng, J. et al. Cancer Cell 2, 323–334 (2002).
Hanahan, D. & Weinberg, R. A. Cell 100, 57–70 (2000).
Macaluso, M. et al. J. Cell. Physiol. 192, 125–130 (2002).
Watt, F. M. EMBO J. 21, 3919–3926 (2002).
Giancotti, F. G. & Ruoslahti, E. Science 285, 1028–1032 (1999).
Tennenbaum, T. Cancer Res. 53, 4803–4810 (1993).
Darnell, J. E. Jr Nature Rev. Cancer 2, 740–749 (2002).
Bharti, A. C. & Aggarwal, B. B. Biochem. Pharmacol. 64, 883–888 (2002).
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Bolotin, D., Fuchs, E. More than skin deep. Nature 421, 594–595 (2003). https://doi.org/10.1038/421594a
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DOI: https://doi.org/10.1038/421594a
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